Protection is not as good as mRNA vaccine. What are the advantages of inactivated vaccine?

On December 30, 2020, Beijing Institute of Biological Products Co., Ltd. quietly published a short announcement in official website. According to the interim analysis results of Covid-19 inactivated vaccine phase III clinical trial, the safety of Covid-19 inactivated vaccine of China Bio-Beijing Company of Sinopharm Group was good after inoculation.After two doses of immunization, the positive conversion rate of neutralizing antibody was 99.2%, and the protective power of vaccine against diseases caused by COVID-19 infection (Covid-19) was 79.34%.

Prior to this, Pfizer and Moderna from the United States also released the research results of phase III clinical trials of their own mRNA vaccines, and the protective power was over 90%. In this way, our vaccines seem to have a little poor protective effect. But be careful,This is not because our technology is not good, but more because of the congenital difference between mRNA vaccine and inactivated vaccine.

Immune protection induced by inactivated vaccine is relatively weak.

Inactivated vaccine is a vaccine made by inactivating virus by physical or chemical methods. Compared with live virus particles, the immunogenicity of inactivated virus is relatively weak, and adjuvant is often needed.

In 2013, a study entitled "Characterization of immune responses induced by activated, live attended and DNA vacuums against Japanese encephalitis virus in mice" was confirmed by Japanese encephalitis virus.Compared with artificial attenuated live vaccine and DNA vaccine, the immune response induced by inactivated vaccine is relatively weak.

Figure 1. Heading of the article

The researchers divided the mice into four groups, injected with inactivated vaccine (INV), live attenuated vaccine (LAV), DNA vaccine (pCAG-JME) and control, and then detected the antibody level in mice. At the end of the experiment, the total antibody titer induced by inactivated vaccine was significantly lower than that of attenuated live vaccine group and DNA vaccine group.

Fig. 2 Antibody level pairs induced by three vaccines

The researchers also detected the levels of different subtypes of IgG induced in the serum of mice, and found that there were differences among the three vaccines. The inactivated vaccine mainly induced IgG type 1 antibody, while the attenuated live vaccine mainly induced IgG type 2a antibody, and the antibody levels of DNA vaccine were both high.

Fig. 3 Different IgG subtypes induced by three vaccines

The researchers also compared the levels of cytokines induced by vaccine and the levels of dendritic cells and Treg in detail, and there were some differences. Anyway,There are some differences in immune response induced by inactivated vaccine, attenuated live vaccine and nucleic acid vaccine. It is not surprising that the protective effect of inactivated vaccine is not as good as that of RNA vaccine.

Inactivated vaccine has the best safety.

Because the clinical data of phase III vaccine of Beijing Institute of Biological Products have not been published in any authoritative journals,Therefore, the safety of inactivated vaccine BBIBP-CorV in China, mRNA vaccine BNT162b2 in Pfizer and mRNA vaccine mRNA-1273 in Moderna Company are examined from the published phase I/II clinical trials of vaccines.Someone has made statistics on the safety data of phase I/II clinical trials of various COVID-19 vaccines, and all the data are shown in the following figure. After the first dose of mRNA-1273 vaccine was injected, the incidence of systemic grade I adverse reactions was 53.3%, grade II adverse reactions were 13.3%, local grade I adverse reactions were 73.3%, and grade II adverse reactions were 13.3%. After injecting the second dose, the incidence of systemic first-class adverse reactions was 20%, and the incidence of second-class adverse reactions was 80%. The incidence of local first-class adverse reactions was 66.7%, and the incidence of second-class adverse reactions was 26.7%. No adverse reactions above grade 3 were found locally or systemically.

However, after injection of Pfizer’s BNT162b2, the incidence of local or systemic adverse reactions was 41.7%, and the incidence of adverse events above grade 3 was 8.3%. For people aged 65-85, the incidence of local or systemic adverse reactions is 25%, and the incidence of adverse reactions above grade 3 is 8.3%.

The results of phase I clinical trial of domestic inactivated vaccine BBIBP-CorV in China show that the incidence of first-grade local or systemic adverse reactions is 33% for people aged 18-59, and that of second-grade adverse reactions is 13%. For people over 60, the incidence of adverse reactions is 29%, and there are no adverse events above grade 3. In the results of Phase II clinical trials, the incidence of Grade I adverse events was 15%, and the incidence of Grade II adverse events was 2%.

Fig. 4 Adverse reactions of various vaccines.

Judging from these data, among the three popular vaccines at present, the safety of inactivated vaccine in China is absolutely the best, not to mention the recent allergic storm of Pfizer vaccine, which has caused rare allergic reactions in dozens of people.

Domestic vaccines with 79% protection and no serious adverse reactions are absolutely safe and effective.Because China’s epidemic prevention and control work is very well done, we have to overcome many difficulties when conducting clinical trials of vaccines. After all, the epidemic situation in COVID-19 is well controlled and there is no condition for clinical trials, which is one of the reasons why the progress of phase III clinical trials lags behind others. We should see that even if our protection efficiency does not exceed 90% in the United States, inactivated vaccine obviously has advantages, such as it is safer and easier to store and transport. Although our protective effect is not as good as the two vaccines in the United States, it has reached the standard of vaccine approval, and the protective effect far exceeds 50%, which is trustworthy.

Pioneer of new market Australia test drive Isuzu D-MAX

    [XCAR test drive original]

    Domestic pickup truck culture started relatively late compared with European and American countries. Both the market environment and consumers’ concept of car purchase are in a relatively immature stage. I believe that when many people talk about pickup trucks, they still link them with cheapness and freight for the first time. Of course, in the past two years, with the introduction of some American pickup trucks, a high-end pickup truck culture focusing on playing with cars has gradually emerged. Looking at the domestic auto market, the current situation of pickup trucks can be said to be serious. One is the cheap pickup truck based on freight, and the other is the American high-end pickup truck just mentioned. The pickup truck market between these two types is basically blank. The Isuzu D-MAX we test-drive today has a clear mission, which is to strive to be a pioneer in this market.

Jiangxi Isuzu 2014 D-MAX

    Since the D-MAX produced by Isuzu’s domestic joint venture manufacturer (Jiangxi Isuzu) has not been officially launched, we chose Australia, where Isuzu has a large number of pickup trucks and the pickup market is relatively mature, to get close contact with this model.However, after three months, we will be able to see the D-MAX model produced by Jiangxi Isuzu in the domestic market.

Jiangxi Isuzu 2014 D-MAX

    Since D-MAX is about to be produced in China, I have to talk about its manufacturer — — Jiangxi Isuzu. For consumers, this is a strange and young manufacturer. Jiangxi ISUZU is a joint-venture vehicle manufacturer established by Japanese Isuzu in China.It is jointly funded by Japanese Isuzu and jiangling motors Group, with the equity ratio of 50:50.

    The model that Jiangxi Isuzu is about to put into production at present is D-MAX pickup truck, which is the protagonist of our test drive today. At the end of next year, Jiangxi Isuzu will also introduce a heavyweight SUV model for production. This model, named MU-X, has been listed in international markets such as Australia.

Jiangxi Isuzu 2014 D-MAX

    When it comes to the history of D-MAX, if you read the picture below, I believe it can bring back some memories. Isuzu pickup truck began to enter China from TF model. At first, it was introduced and produced by Qingling. Later, domestic independent brands began to copy this model.

Jiangxi Isuzu 2014 D-MAX

    Since it is a pioneer in the domestic mid-range pickup market, does D-MAX really have no competitors? From the perspective of head-on confrontation, there is really no pickup truck model in the domestic mid-range pickup truck market that can be similar to D-MAX in price, configuration and technical level. But from the perspective of positioning, it seems that only Toyota’s hilux can be regarded as a competitor.

Jiangxi Isuzu 2014 D-MAX

    Although Zhengzhou Nissan’s D22 pickup truck is similar to D-MAX in positioning and design, the D22 model is too old to compete with D-MAX in the same generation. The Nissan Navara pickup truck, which can really compete with D-MAX, has no plans to introduce it at present.

Jiangxi Isuzu 2014 D-MAX

Jiangxi Isuzu 2014 D-MAX

    The positioning of Isuzu D-MAX was introduced by the author at the beginning, and it mainly focuses on the mid-range pickup market. In addition to the outstanding loading capacity of pickup trucks, D-MAX has excellent performance in the interior space and passability. Although it is the pioneer of mid-range pickup trucks in China at present, it is also in sync with the international level in terms of technology. However, if D-MAX wants to make some achievements in this strange emerging market, it is indeed difficult to see the current domestic pickup truck environment and road regulations. For example, in a first-tier city like Beijing, the driving of pickup trucks will still be greatly restricted, which is an unavoidable reality.

Jiangxi Isuzu 2014 D-MAX

Notice of the General Office of Beijing Municipal People’s Government on the Establishment of Beijing Central Wholesale Market Management Committee for Vegetables, Fruits and Flowers

Beijing Zhengban made [1995] No.20

The people’s governments of the districts and counties, the commissions, offices and bureaus of the municipal government, and the municipal institutions:

  In order to meet the needs of the construction of the socialist market economic system, speed up the construction of the market system in this city, strengthen the macro-control of the municipal government on the agricultural products market, and prosper and stabilize the agricultural products market in the capital, the municipal government has decided to set up the Beijing Central Wholesale Market Management Committee of Vegetables, Fruits and Flowers, which is a fairly bureau-level institution sent by the municipal government to act as the relevant administrative functions of the municipal government.

  The main duties of the Beijing Central Wholesale Market Management Committee of Vegetables, Fruits and Flowers are: to formulate and organize the implementation of the phased planning and construction plan according to the overall market plan determined by the municipal government, and to handle matters such as land expropriation, project development, land use right transfer, relocation and resettlement of farmers (residents) and enterprises within the overall market plan; In conjunction with relevant departments, review and handle the project initiation, feasibility report, contract articles of association, architectural design and construction of construction projects within the market, and examine and approve various enterprises and import and export agency business in the market; Supervise and manage enterprises and institutions in the market according to law; To study and formulate specific policies, systems and measures for the development, construction, operation and management of this market.

  The internal organization of Beijing Central Wholesale Market Management Committee of Vegetables, Fruits and Flowers shall be separately approved by the Municipal Compilation Office. 

  March 25, 1995  

Multi-site sampling to detect coliform bacteria in tableware and rice noodles Expert: Many reasons are secondary pollution.

  Recently, the market supervision departments in many places issued a notice on the unqualified food sampling list. The Paper combed and found that it involved many problems such as pesticide residues and microbial pollution. The market supervision department has carried out verification and disposal work.

  It is noteworthy that coliforms were detected in tableware and rice noodles in the unqualified sampling list of several batches of food published by Tai ‘an Municipal Market Supervision Administration and Baise Municipal Market Supervision Administration.

  Why are coliforms detected in tableware and rice noodles? Kai Zhong, deputy director of Kexin Food and Nutrition Information Exchange Center, said that coliforms mainly come from the intestines of warm-blooded animals, but they are widely distributed in nature. Dishes, rice noodles and so on have coliforms exceeding the standard, mostly because of secondary pollution.

  Many enterprises were found to contain coliforms in their products.

  On July 5th, Tai ‘an Municipal Market Supervision Administration issued the information circular on food safety sampling inspection (hereinafter referred to as the circular), which disclosed problems such as excessive pesticide residues and microbial pollution.

  According to the notice, coliforms were detected in the tableware plates of Fuchunyuan Restaurant in Taishan District and Shandong Xiaolongxiao Jiutian Catering Management Co., Ltd. in Taishan District. According to the national food safety standards, coliforms should not be detected in tableware.

  Tai ‘an Municipal Market Supervision Administration said in the notice that the market supervision department of the place where the production and operation enterprises are located has ordered the enterprises to find out the product flow, recall and remove the unqualified products, control risks, file an investigation, and analyze the reasons for rectification. The unqualified products involved have been verified and disposed of as required.

  The Paper combed and found that Baise Municipal Market Supervision Administration had previously released the 26th food safety supervision and sampling information announcement in 2021 on July 1, which also showed that the prepared fresh and wet rice noodles sold by Guangxi Tiandong Weimeijia Agricultural Products Development Co., Ltd. and tianlin county Huaxu Food Co., Ltd. were all found to have coliforms.

  Kai Zhong, deputy director of Kexin Food and Nutrition Information Exchange Center, said that coliforms are the general name of many bacteria, including Escherichia coli. It is a hygienic indicator bacterium, but it does not lead to disease if it is detected. The higher the detection value, the greater the possibility. Coliform bacteria can be detected in many foods, but as long as there are no pathogenic bacteria, it will generally not cause health hazards. As for the source of coliform bacteria, Kai Zhong said that coliform bacteria mainly come from the intestines of warm-blooded animals, but they are widely distributed in nature. Dishes, rice noodles and so on have coliform bacteria exceeding the standard, mostly because of secondary pollution.

  According to the interpretation information released by the market supervision department, coliform bacteria is one of the commonly used indicator bacteria for food pollution at home and abroad. The detection of coliform bacteria in food suggests that it is more likely to be contaminated by pathogenic bacteria (such as Salmonella, Shigella and pathogenic Escherichia coli). Excessive coliform bacteria may be caused by the pollution of processing raw materials and packaging materials of products, or the pollution of products by production equipment and environment such as personnel and tools during production, and the incomplete sterilization of products with sterilization technology.

  A variety of foods were found to have excessive drug residues.

  In addition to coliform bacteria, some enterprises have been found to have drug residues and other problems. In the notice issued by Tai ‘an Municipal Market Supervision Administration on July 5, the bureau disclosed that the content of "procymidone" in leeks sold by Baxianju Commercial Bank in Ningyang County and Yanzhuang Haiwei Supermarket in Daiyue District was higher than the national food safety standard.

  The Paper combed and found that in recent food sampling notices issued by many market supervision administrations, the problem of unqualified drug residue detection of enterprise-related products appeared.

  On July 2nd, the 7th notice of Gansu Provincial Market Supervision Bureau on the sampling inspection of unqualified food showed that chloramphenicol, a drug banned from food animals, appeared in Jinghui brand acacia honey produced by Gansu Jinghui Bee Industry Co., Ltd..

  On July 5, 2021, Jilin Provincial Market Supervision and Management Department’s 27th notice on unqualified food showed that the carp sold by Fengyun Aquatic Products Company in Automobile Industry Development Zone, Wuchang Fish sold by Yixin Aquatic Products Store in Chaoyang District and snakehead sold by Guo Di Seafood Wholesale Company in Kuancheng Agricultural Products and Aquatic Products Market were all found to exceed the standard.

  The attachments of the above-mentioned relevant notices show that excessive coliforms are likely to cause intestinal diseases such as dysentery, which may cause symptoms such as vomiting and diarrhea. The pesticide procymidone is irritating to people’s eyes and skin. Long-term consumption of leeks with excessive procymidone residues may cause neurological disorders.

  The market supervision department reminds consumers that when they find the unqualified products involved in the notice, they can call the 12315 hotline to complain or report.

Institutional guarantee for high-quality development

  Perfecting the basic socialist economic system is the institutional guarantee for high-quality economic development and the construction of a modern and powerful country. Standing at a new historical starting point, we should adhere to and improve the socialist basic economic system and promote high-quality economic development in accordance with the requirements put forward by the Fourth Plenary Session of the 19th CPC Central Committee, closely focus on the goal of high-quality development, firmly grasp the important key point of adhering to and improving the socialist basic economic system, and vigorously promote China’s economy to achieve high-quality development.

  The socialist basic economic system is a great creation of the party and the people and an institutional guarantee for high-quality development.

  The Fourth Plenary Session of the 19th CPC Central Committee took "public ownership as the main body, multiple ownership economies developing together, distribution according to work as the main body, multiple modes of distribution coexisting, and socialist market economic system" as Socialism with Chinese characteristics’s basic economic system, which is the latest summary and development of China’s socialist basic economic system, a major institutional innovation for China’s socialist basic economic system, and also an important theoretical innovation, reflecting the combination of theoretical innovation, institutional innovation and practical innovation. These economic systems are interrelated and mutually promoted, forming a socialist basic economic system, which is a great creation of the party and the people and an institutional guarantee for high-quality development.

  The dominant position of public ownership has maintained the nature of the socialist system and the socialist direction of China’s economic development.Adhering to the common development of various forms of ownership has mobilized the enthusiasm of all parties, released new vitality for economic development, improved the enthusiasm and creativity of market players, and cultivated new kinetic energy for economic development. This system maintains the advantages of public assets in quantity, strengthens the control of public economy in important areas of national economy in quality, and realizes the combination of quality and quantity. By improving relevant laws, regulations and policies, we will promote and guide the healthy development of the non-public sector of the economy, so that the public sector of the economy and the non-public sector of the economy can work together to better serve the economic development in the new era.

  The ownership structure with public ownership as the main body and multiple ownership economies developing together determines the distribution system with distribution according to work as the main body and multiple modes of distribution coexisting.The ownership system determines the distribution system, the dominant position of public ownership determines the distribution according to work, and the coexistence of various forms of ownership determines the coexistence of various modes of distribution. Taking this distribution system as the content of the basic socialist economic system ensures the long-term stability of this distribution system. The basic economic system with distribution according to work as the main body and multiple modes of distribution coexisting plays a positive role in narrowing the income gap, avoiding polarization and improving the income of workers. This distribution system has improved the mechanism that labor, capital, land, knowledge, technology, management, data and other production factors determine their remuneration according to their contributions, and improved the redistribution adjustment mechanism with taxation, social security and transfer payment as the main means, which can rationally adjust the distribution relationship between urban and rural areas, regions and groups, protect legitimate income and ban illegal income.

  Raising the socialist market economic system to a basic economic system is an affirmation of the combination of socialist system and market economy.The socialist market economy is the combination of socialist system and market economy. Perfecting the socialist market economy system is to build an economic system with "effective market mechanism, dynamic micro-subjects and moderate macro-control", which is a combination of strong market, strong government and strong enterprises. The Fourth Plenary Session of the 19th CPC Central Committee brought the socialist market economy system into the basic economic system, which deepened our party’s understanding of the role of market economy and the relationship between market and government, and showed the world that the direction of developing socialist market economy in China will remain unchanged in the future.

  On the basis of adhering to the main role of public ownership economy, actively explore various forms of public ownership to promote high-quality economic development.

  The Decision of the Fourth Plenary Session of the 19th CPC Central Committee put forward "exploring various forms of public ownership" in the paragraph of state-owned economic reform. Putting "exploring various forms of public ownership" in the first sentence has profound significance.

  On the basis of adhering to the dominant position of public ownership, we can explore the diversification of public ownership.Public ownership and its realization form are the relationship between content and form. Under the premise of adhering to the dominant position of public ownership, the realization form of public ownership can be diversified, and the organizational form and management mode of public assets can be diversified with the goal of maintaining and increasing the value of public assets. The choice of the realization form of public ownership mainly depends on the development level of productive forces. At present, China is still in the primary stage of socialism, and the multi-level and unbalanced development of productive forces in the primary stage of socialism determines the diversification of the realization form of public ownership. The diversification of the forms of public ownership includes two meanings: the first meaning is that the forms of public ownership are diversified, and its own diversification includes ownership by the whole people and collective ownership, etc., and the diversified forms of public ownership can be combined with each other to form more diversified forms of public ownership. At the same time, the carrier of property rights of public ownership is also diversified, and the management system and mode of public ownership can also be diversified. The second meaning is that public ownership coexists with other forms of ownership in the primary stage of socialism, forming an ownership structure with public ownership as the main body and multiple ownership systems coexisting. According to the diversification of public ownership forms, we can promote the separation of ownership and management rights and realize the separation of state-owned economy and state-owned assets in concept and operation, which further shows that the realization form of public ownership economy is not only the type of state-owned enterprises, but also can explore various forms of realization.

  The state-owned economy should adjust its strategic layout, with progress and retreat.General Secretary of the Supreme Leader has made many speeches on the structural adjustment of the layout of the state-owned economy. He proposed, "Speed up the layout optimization, structural adjustment and strategic reorganization of the state-owned economy. Advance and retreat, do something different, innovate and develop a batch, reorganize and integrate a batch, clean up and withdraw a batch, promote the concentration of state-owned capital in strategic key areas and advantageous industries, and accelerate the strategic adjustment of the state-owned economy. " According to the exposition of the Supreme Leader General Secretary and the spirit of the Fourth Plenary Session of the 19th CPC Central Committee, we need to deepen the supply-side structural reform, adjust and optimize the layout structure of the state-owned economy, revitalize the manufacturing industry and the real economy, actively promote the transformation and upgrading of traditional industries, and accelerate the development of strategic emerging industries. In the economic development of the new era, around the major strategy of serving the country, we should persist in making progress and retreating, and do something different. We should invest more state-owned capital in important industries and key areas that are related to the lifeline of the national economy, especially strategic emerging industries, promote the upgrading of economic structure, optimize the layout of state-owned assets and state-owned enterprises, and cultivate new economic growth points.

  Take mixed ownership as a new realization form of public ownership.The Fourth Plenary Session of the 19th CPC Central Committee included the reform of mixed ownership in the scope of state-owned economy, which is to bring the reform of mixed ownership into the scope of ownership reform and explore the realization form of public ownership through the reform of mixed ownership. This means that the mixed ownership economy with cross-shareholding and mutual integration of state-owned capital, collective capital and non-public capital is an important realization form of the basic economic system. This form is conducive to amplifying the function of state-owned capital, improving the competitiveness of state-owned capital, expanding the development space of private capital, and promoting and developing all kinds of ownership capital together. As a new form of public ownership, the reform of mixed ownership is not only a breakthrough in the reform of state-owned enterprises, but also brings new opportunities for the development of private enterprises. Through the promotion of mixed ownership reform, we can promote the integrated development of state-owned capital and non-public capital, thus stimulating the endogenous power of China’s high-quality economic development.

  Improve the policy system to support the new form of public ownership.Exploring the new realization form of public ownership economy is to better adhere to the dominant position of public ownership, and developing mixed ownership economy is a new exploration of the realization form of public ownership and an important way to consolidate China’s basic economic system. However, the development of mixed ownership economy needs to improve the policy system supporting the new realization form of public ownership, and focus on solving the reform motive force of mixed ownership, the equal protection of all kinds of property rights in the reform of mixed ownership and the operation mechanism of mixed ownership. Focusing on the development of mixed ownership, it is necessary to highlight the transformation of operating mechanism, explore a management and control model that adapts to the development of mixed ownership economy, and enhance the enthusiasm and initiative of social capital to participate in the reform of mixed ownership of state-owned enterprises. We will create an integrated development of various ownership entities, use resource elements equally according to law, and form a market environment that is open, fair and just to participate in competition and equally protected by law.

  Combine the improvement of the high-level socialist market economic system with the construction of a high-level open economic new system to promote high-quality economic development.

  Achieving high-quality economic development requires certain conditions. This condition is the combination of the role of the government and the role of the market. The combination of a high-level domestic socialist market economic system and a high-level opening-up system is the institutional and institutional basis for achieving high-quality development. To this end, we should combine the improvement of the high-level socialist market economic system with the construction of a high-level open economic new system to promote high-quality economic development.

  On the basis of giving play to the decisive role of the market in resource allocation, we should correctly handle the relationship between the government and the market, give full play to the role of the government, and combine the role of the government with the role of the market to promote high-quality economic development.With the goal of high-quality development, we should correctly handle the relationship between the government and the market, realize the combination of the government and the market on the basis of effectively exerting the decisive role of the market, and accelerate the high-quality development. On the one hand, realize the combination of government function and market function. In the process of economic development, we should follow the laws of market economy and improve the market system. Clarify the decisive role of the market in resource allocation and truly change the mode of economic development. At the same time, we should change government functions, give play to the role of supervision, guidance and regulation, and play the role of government through macroeconomic regulation, making up for market failures and the supply of public goods. On the other hand, a modern economic system is established through the combination of government and market. Build an economic system with effective market mechanism, dynamic micro-subjects and moderate macro-control. Through the combination of the role of government and market, on the basis of quality reform, efficiency reform, power reform and improving total factor productivity, we will accelerate the construction of a modern economic system with supply-side structural reform as the main line. Build a modern industrial system with coordinated development of real economy, scientific and technological innovation, modern finance and human resources.

  Realize the combination of a high-level socialist market economy and a higher-level open economic new system to promote high-quality development.On the one hand, China should build a high-level socialist market economic system. Build a high-standard market system, speed up the improvement of the property rights system, and realize effective incentives for property rights. Accelerate the market-oriented allocation of factors and realize the free flow of factors. Create a unified, open and competitive market environment. Improve the property rights definition system, property rights allocation system and property rights transaction system, and promote the market-oriented allocation of factors. In accordance with the spirit of the Fourth Plenary Session of the 19th CPC Central Committee, improve the system and mechanism of scientific and technological innovation, improve the system and mechanism of encouraging and supporting basic research and original innovation, and improve the incentive mechanism of scientific and technological talents and the policy system of scientific and technological management. Establish a technological innovation system with enterprises as the main body, market orientation and deep integration of Industry-University-Research. On the other hand, it is necessary to build a new open economic system at a higher level. The Third Plenary Session of the 18th CPC Central Committee proposed to build a new open economic system, and the Fourth Plenary Session of the 19th CPC Central Committee proposed to build a new open economic system with a higher level. Comparatively speaking, the requirements for opening up are higher and the level is higher, which means that in the new era, we should implement comprehensive opening-up in a wider scope, in a wider field and at a deeper level. In order to achieve this goal, we should strive to create a market-oriented, rule-based and international business environment, further promote the construction of a new open economic system, and promote high-quality economic development with a high level of openness.

  Author: Ren Baoping, Dean and Professor of Graduate School of Northwest University and Changjiang Scholar of Ministry of Education.

Department 17: study the extension of the exemption policy for new energy vehicle purchase tax, and guide the downward adjustment of the charging service fee.

On July 7, the Ministry of Commerce and other 17 departments issued the "Notice on Several Measures for Invigorating Automobile Circulation and Expanding Automobile Consumption", which pointed out that we should support the consumption of new energy vehicles and study the extension of the vehicle purchase tax exemption policy for new energy vehicles after its expiration. Carry out in-depth activities of new energy vehicles to the countryside, encourage qualified places to introduce support policies to the countryside, guide enterprises to increase preferential activities, and promote the consumption and use of new energy vehicles in rural areas.

The following is the full text of the notice:

People’s governments of all provinces, autonomous regions and municipalities directly under the Central Government, Xinjiang Production and Construction Corps:

The automobile industry is a strategic and pillar industry of the national economy. In order to further invigorate automobile circulation, expand automobile consumption, help stabilize the basic economy and ensure the improvement of people’s livelihood, with the consent of the State Council, relevant matters are hereby notified as follows:

First, support the purchase and use of new energy vehicles

(a) to promote cross-regional free circulation, to break the local protection of the new energy vehicle market, each region shall not set the local new energy vehicle models for the record directory, and shall not set unreasonable vehicle parameter indicators for the sales and consumption subsidies of new energy vehicle products.

(2) Support the consumption of new energy vehicles, and study the extension after the expiration of the vehicle purchase tax exemption policy for new energy vehicles. Carry out in-depth activities of new energy vehicles to the countryside, encourage qualified places to introduce support policies to the countryside, guide enterprises to increase preferential activities, and promote the consumption and use of new energy vehicles in rural areas.

(3) Actively support the construction of charging facilities, accelerate the construction of charging facilities such as residential communities, parking lots, gas stations, expressway service areas, passenger and freight hubs, and guide charging pile operators to appropriately reduce charging service fees.

Second, accelerate the active second-hand car market

(four) to cancel the unreasonable restrictions on the development of second-hand car distribution, and make it clear that enterprises with registered residence and business premises outside the second-hand car trading market can carry out second-hand car sales business. For enterprises engaged in new car sales and used car sales, the business scope shall be uniformly registered as "automobile sales" and put on record according to relevant regulations. The filing enterprise shall truthfully fill in the business content and other information, and the commercial department shall promptly push the information of the filing enterprise to the public security organ and the tax department. Since October 1, 2022, if a registered automobile sales enterprise purchases a used car from a natural person, it is allowed to issue a unified invoice for the sale of used cars in reverse and handle the transfer registration procedures accordingly.

(five) to promote the commercialization of second-hand cars, and to clarify that automobile sales enterprises should conduct accounting for second-hand cars purchased and used for sales according to the unified accounting system of the state. Since October 1, 2022, when a registered automobile sales enterprise applies for the transfer registration of a small non-operating used car, the public security organ will implement the management of separate endorsement and issue a temporary license plate. For cities where automobile purchases are restricted, it is clear that used cars purchased by automobile sales enterprises and used for sales do not occupy the number plate index.

(VI) Support the large-scale development of second-hand car circulation, strictly implement the policy of completely canceling the restrictions on the movement of second-hand cars in all regions, and cancel the restrictions on the movement of small non-operating second-hand cars that meet the national emission standards from August 1, 2022, so as to promote the free circulation of second-hand cars and the cross-regional operation of enterprises. Since January 1, 2023, if a natural person sells three or more used cars that have been held for less than one year in a natural year, automobile sales enterprises, used car trading markets, auction enterprises, etc. shall not issue a unified invoice for the sale of used cars, and shall not go through the transaction registration procedures, and the relevant departments shall handle it according to the regulations. Public security organs and tax authorities share verification information, and tax authorities make full use of the shared information to provide information support for relevant enterprises to issue invoices.

Third, promote automobile renewal consumption

(seven) to encourage the comprehensive use of economic and technological means to promote the withdrawal of old vehicles, conditional areas can carry out the old car, accelerate the elimination of old vehicles.

(eight) improve the recycling system of scrapped motor vehicles, and support qualified enterprises to obtain the qualification for recycling scrapped motor vehicles. Enterprises that have obtained qualifications before the implementation of the Detailed Rules for the Management of Scrap Motor Vehicle Recycling, such as those unable to re-complete the qualification confirmation on schedule due to the impact of the COVID-19 epidemic, may be postponed until March 1, 2023. Increase the support for the construction projects of scrapped motor vehicle recycling enterprises. In principle, the nature of the land for enterprise construction projects should be industrial land. For enterprises that have obtained the qualification of scrapped motor vehicle recycling and projects under construction that have obtained the approval of land use or the planning permission of construction projects within 3 months after the issuance of this document, the land should be used according to the determined purposes.

Fourth, promote the sustained and healthy development of parallel automobile imports

(9) Support the parallel import business of automobiles in the import port area of complete automobiles, and the parallel import business of automobiles can be carried out at the import port of complete automobiles after the work plan of parallel import of automobiles is approved by the provincial people’s government and reported to the Ministry of Commerce for the record. We will improve the compulsory product certification and information disclosure system for parallel imported cars, allow enterprises to make a commitment that the imported cars will continue to meet the national six emission standards, and continue to implement the relevant policy requirements for the OBD test and data information of parallel imported cars in the environmental protection information disclosure link.

Fifth, optimize the automobile use environment

(ten) to promote the construction of urban parking facilities, effectively improve the effective supply level of urban parking facilities, accelerate the application of new technologies and new models, and promote the sharing of parking resources and the matching of supply and demand. The newly-built residential area will build parking facilities in strict accordance with the urban parking planning and the construction standards of complete residential communities. Actively expand new parking facilities in combination with urban renewal actions such as the transformation of old urban communities. Make rational use of civil air defense projects, underground spaces of parks and green spaces, and tap the potential to build more parking facilities. All localities should improve the parking fee policy, strengthen the policy support of capital land use, and increase the use of local debt to support the construction of qualified parking facilities.

(11) Develop automobile cultural tourism and other consumption, support the construction and operation of automobile sports events, automobile self-driving sports camps and other projects in terms of land use, study and formulate the conditions for the identification of traditional classic vehicles, and promote the development of traditional classic car-related industries and automobile culture such as exhibition, collection, trading and competitions.

VI. Enriching automobile financial services

(12) Encourage financial institutions to reasonably determine the down payment ratio, loan interest rate and repayment period under the premise of compliance with laws and controllable risks, and increase credit support for automobile consumption. We will develop auto financing leasing in an orderly manner, encourage auto manufacturers, sales enterprises and financing leasing enterprises to strengthen cooperation and increase the supply of financial services.

All regions and relevant departments should earnestly strengthen organization and leadership, refine work measures according to their responsibilities, promote relevant policies and measures to take effect as soon as possible, and further promote the recovery of automobile consumption and the release of potential.

China and South Africa have formed a stable and strong cooperative relationship in the supply chain and industrial chain.

  CCTV News:2023 is the 25th anniversary of the establishment of diplomatic relations between China and South Africa, and it is also the BRICS "South Africa Year". At the press conference on August 17th, a spokesman for the Ministry of Commerce said that in recent years, under the strategic guidance and personal promotion of the two heads of state, the economic and trade cooperation between China and South Africa has made great progress.

  Bilateral trade grew rapidly. In 2022, the bilateral trade volume between China and South Africa reached US$ 56.74 billion, a year-on-year increase of 5%, a record high in eight years. In the first half of 2023, it was further accelerated, with an increase of 11.7%. China has been South Africa’s largest trading partner for 14 consecutive years, and South Africa has been China’s largest trading partner in Africa for 13 consecutive years.

  Two-way investment has achieved remarkable results. China is one of South Africa’s major sources of investment, with an investment stock of more than 10 billion US dollars, covering finance, home appliances, automobiles, mining, energy and other fields. South Africa is also the African country that actually invests the most in China, and the two sides have formed a stable and strong cooperative relationship in the supply chain and industrial chain.

  Cooperation under the multilateral framework is strong and effective. The two sides jointly safeguard the non-discriminatory, open, inclusive and transparent multilateral trading system, emphasize the importance of multilateralism, and jointly promote the success of the 12th WTO Ministerial Conference beyond expectations. Relying on the BRICS cooperation mechanism, we issued a unanimous voice to support the multilateral trading system, release the potential of the digital economy, promote trade and investment and sustainable development, and strengthen supply chain cooperation.

On the Long March Road, the good sons and daughters’ Long March songs will be circulated forever.

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The Long March is a manifesto

The Long March is a propaganda team.

Long March is a seeder.

       In October, 1934, the Chinese Red Army of Workers and Peasants began a long March that was arduous and shocked the world. According to statistics, during the Long March, the Central Red Army passed through 11 provinces, crossed 18 mountains, crossed 24 rivers, crossed grasslands and climbed snow-capped mountains, with a journey of about 25,000 miles. Finally, in October 1936, the three main forces of the Red Army joined forces, marking the victory of the Long March and creating a great miracle in human history! Through the Long March, the Communist Party of China (CPC) publicized our Party’s anti-Japanese proposition of going northward, sowed revolutionary kindling in various places along the Long March, and also expanded the influence of the Communist Party of China (CPC) and the Red Army in the whole country.

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       On August 1, 1965, in order to commemorate the 30th anniversary of the victory of the Red Army’s Long March, a large-scale vocal suite "Long March Suite — — The red army is not afraid of the expedition.

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       On the stage of this issue of Le Ling Singing, we welcome an old comrade-in-arms chorus art troupe formed by retired actors of Long March Suite and some singers who love Long March Suite. They will tell us why Long March Suite has been sung for decades and how it has become a classic among classics.

       Let’s meet the actors who premiered 55 years ago. Time can only take away youth, but it can’t take away lofty ideals and firm beliefs!

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Chorus of revolution

The revolution of chorus

       Referring to the response after the premiere of "Song of the Long March", as the original general director, Grandpa Han Rongshi, who is 88 years old this year, said: "The situation at that time is still vivid. After the performance, it was an instant hit and was warmly welcomed. Comrade Zhu Jianer, a musician, wrote an article saying that "Long March Songs" is a chorus of revolution and a revolution of chorus. The chorus of revolution refers to the content of "Long March Songs" and describes the whole process of the Long March. The revolution of chorus is about form. It breaks through the original form of chorus wearing a dress and standing on the stage like a wall, adding performances, actions and scenes, which is very visual and makes the audience enjoy and be satisfied. "

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       Wang Shuli, a violinist who also premiered, is currently the head of the Chorus Art Troupe of the old comrades-in-arms. He said that the reason why the Long March Ensemble is praised as a classic work in chorus is that it has achieved "three unifications".

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Walking through Qian Shan

Highlight the revolutionary responsibility

       A landmark classic works, the reason why it can be sung so far, the reason why it can move people’s hearts, this is inseparable from its artistic creation. Every time I recall this past, I have been performing for more than 50 years, and Ma Ziyue, the bass singer who has performed more than 1,000 Long March Songs, is still impassioned.

The image is full of glory

Classic eternal inheritance

       In the process of creation, rehearsal and performance, The Long March Songs received the cordial care and guidance from Premier Zhou Enlai. After the premiere on August 1, 1965, Premier Zhou watched the Long March Songs three times in a month on August 6, August 24, August 27, and learned every song. In the same year, 18 members of the choir also visited Albania with Premier Zhou, including Han Rongshi, Ma Ziyue and Yang Zhenhui.

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       Premier Zhou, who loves "Song of the Long March" so much, only left a group photo with the members. Speaking of this past, the 87-year-old grandmother Xie Gongcan, the former conductor assistant of the Long March Songs, was still very excited.

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       As an epic red classic, "Long March Songs" has been sung all over the country, infecting generations of Chinese people, and has been sung ever since. It has been 55 years since it premiered in 1965. Although they were full of youthful hair, they still used their songs to inherit the Long March Songs and carry forward the spirit of the Long March. Today, on the stage of "Singing in the Age of Music", they are once again dressed in battle, and continue to present us with the original classic chapter with the passion of that year.

"Singing in Old Age, National Chorus Competition for the Elderly"

First broadcast of CCTV-1

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Replay CCTV-12

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In the first half of 2022, the sales of pickup trucks in the United States, the big three of the United States declined in an all-round way.

A few days ago, the pickup truck market obtained the sales data of pickup trucks in the United States in the first half of 2022. In June 2022, the pickup truck market in the United States sold 233,113 new cars, which was 6.9% lower than that of 250,349 in 2021. From January to June, 1,341,611 new cars were sold, down by 11.4% compared with the same period in 2021. Since the global epidemic in COVID-19 in 2020, the pickup truck market in the United States has been affected by factors such as insufficient production capacity and sluggish economy, and its sales volume has declined for two consecutive years. Up to now, it has continued the previous downward trend in 2022, and it is difficult to recover in the short term.

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 1

According to statistics, in the first half of 2022,Ford F-series, Ram pickup truck and Chevrolet Sorod still occupy the top three positions, and GMC Sierra surpassed Toyota Tacoma to rise to fourth place; Chevrolet Colorado,Nissan Frontier and GMC CanyonAfter the replacement of medium-sized pickup trucks, the sales performance is remarkable, and emerging pickup trucks such as Ford Maverick and Hyundai Santa Cruz have injected new vitality into the American market; Rivian R1T, Hummer EV and other emerging electric pickup products began to be delivered gradually.

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 2

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 3

Ford is the absolute overlord of the pickup truck market in the United States, and F-series pickup trucks sell new cars in June.57,673 vehicles, up year on year.26.3%, but even so, it is difficult to hide the overall decline. Only new cars are sold from January to June.299,345 vehicles, a year-on-year decrease of 17.3%. If the overall downward trend cannot be reversed, the annual sales of Ford F-series pickups will probably fall below the 700,000 mark in 2022.The continuous decline in Ford’s sales has also reduced its lead over Chevrolet and Ram, only less than 40,000 vehicles ahead of the second place, and it may be surpassed with a little carelessness. To this end, Ford promptly followed up the electrification reform, and the F-150 Lightning has now won hundreds of thousands of orders.In the future, Ford will maintain its leading position through multi-dimensional development.

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 4

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 5

In June 2022, Chevrolet Sorod sold a new car.46,313 vehicles, a year-on-year decline.16.7%, selling new cars from January to June.261,827 vehicles, a year-on-year decline.10.1%, also in an endless decline. Chevrolet Sorod completed the update and change in September 2021, focusing onThe interior and configuration have been upgraded and alsoThe ZR2 cross-country performance version of Sorod was introduced.Make it more competitive in the face of the new Ford F-150 and the new Ram 1500. Chevrolet is also keenly aware of the fiery atmosphere of the current electric pickup market, which was released in January 2022.Silverado EV model,The new car is the second pure electric pickup truck product commonly launched after Hummer EV, and it is also built with the brand-new third-generation pure electric platform Ultium Autoenergy platform, which will provide ideas for the next stage upgrade and development of Chevrolet pickup truck models.

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 6

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 7

2021 is the highlight moment of Ram pickup.Not only is it a rare brand with year-on-year sales growth in the American market, but it also surpassed Chevrolet Sorod to become the second place. However, after entering 2022, Ram failed to resist the overall market decline. In the first half of the year, only 244,984 new cars were sold, down 21.7% compared with the same period of last year, making it the largest decline among the three American giants. Ram launched Ram TRX last year, which was enough to shake the status of the Raptor’s performance pickup truck, which made the Ford F-150 Raptor feel great pressure. Its first electric pickup truck Ram 1500 EV was also scheduled for 2024, which launched an all-round impact on Ford. However, the update speed and range of the conventional Ram 1500 model are obviously insufficient, and the Stellantis brand after integrated management needs to work harder on pickup trucks.

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 8

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 9

GMC Sierra and Chevrolet Sorod belong to GM.GMC, as a high-end luxury brand of GM, has always focused on top luxury routes, whether it is pickup trucks. Sierra pickupPreviously, it ranked fifth in the sales list all the year round, but this year it surpassed Toyota Tacoma.Sales in the first half of this year were118,938 vehicles, a year-on-year decline.14.1%。GMC SierraUshered in a new generation in October last year.In order to better fight against Ram 1500, it has been upgraded in all directions on the basis of the previous generation, and the top Denali Ultimate and AT4X versions that break through the previous generation have been introduced. GMC Sierra will also launch an electric version in the future, which is developed based on GM’s new Ulitum platform. The specific production time is tentatively set at around 2023.

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 10

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 11

ToyotaTacoma is the king of medium-sized pickup trucks in the United States, occupying the throne of the sales champion of medium-sized pickup trucks in the United States all the year round, with a sales volume of 108,648 in the first half of 2022.Car,It fell 22% year-on-year. Tacoma is the only "foreign" product that has achieved great success in the United States. It is more popular than its big brother, Toyota Tantu, and the car is currently in a replacement cycle. It is reported that the next generation model will share the R&D platform with 4Runner, brand-new Hilux, brand-new smooth road and brand-new land patrol, so that Toyota products can be better pushed to the global market, so it is not impossible if the new Tacoma production version of the real car is highly similar to the brand-new smooth road in the future. At the same time,Toyota recently announced its electrification development strategy, including an electric pickup truck product, which is supposed to be Tacoma electric version.

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 12

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 13

Toyota smooth road,Chevrolet Colorado,Nissan Frontier,Jeep gladiator,Ford Maverick,Several models of Ford Ranger constitute the third group. Among them, Toyota, after upgrading, has made remarkable progress. From January to June, it sold 44,316 new cars, up 1% year-on-year, which not only got rid of the previous continuous decline, but also rushed to the position of the leader of the third group. Chevrolet Colorado also has a good performance this year. Thanks to the renewed enthusiasm of consumers for small and medium-sized pickup trucks, the sales volume of the car reached 44,190 from January to June, up 13.7% year-on-year, and the growth rate in June reached 48.4%. Nissan Frontier has also been reborn due to changes in the market wind direction, with sales of 43,168 vehicles in the first half of the year, with a year-on-year increase of 63.6%.

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 14

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 15

As the saying goes, people’s joys and sorrows are not connected, so are car sales. At present, small and medium-sized pickup trucks have become a hot spot of consumption again. Jeep Gladiator sold 38,756 vehicles in the first half of the year, down 20.6% year-on-year. Perhaps it was abandoned by consumers because of its rich play attributes and low use value. FordMaverick, as a new compact product launched by Ford for market hotspots, well explains the importance of grasping the outlet. The sales volume of new cars in the first half of the year was 38,753, showing a relatively strong growth momentum, and it is expected to become an important sales pillar of Ford pickup trucks in the future. Ford Ranger, once the leader of the third group, fell to the end of the group this year, with sales of only 33,840 vehicles in the first half of the year, down 42% year-on-year. It seems that it will take time for the new Ranger to truly adapt to the American market.

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 16

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 17

At the bottom of the list isHonda Ridgeline,Modern Santa Cruz,GMC Canyon andNissan Titan, in which Honda Ridgeline’s sales in June this year increased by 5.5% year-on-year, but the cumulative sales from January to June are still in a state of decline; As a pure pickup truck, Hyundai Santa Cruz’s monthly sales are gradually increasing, even surpassing Nissan Titan and GMC Canyon;. GMC Canyon sold 13,662 vehicles in the first half of the year, up 9.4% year-on-year;Nissan Titan sold 11,212 new cars in the first half of the year, down 36.9% year-on-year. It is still in an endless decline. It is reported that Nissan is preparing to give up Titan pickup trucks and there will be no next-generation models.

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 18

In the first half of 2022, the sales of pickup trucks in the United States declined in an all-round way-Figure 19

In 2019, Tesla Cybertruck reshaped pickup products with its subversive design concept, which opened the prelude to competition in the field of electric pickup trucks. Subsequently, Ford F-150 Lightning, Hummer EV, Rivian R1T, Chevrolet Silverado EV and other heavy models came out one after another, which refreshed people’s understanding of electric vehicle products. At present, Hummer EV and Rivian R1T have officially entered the delivery link. Rivian R1T delivered 1,600 new cars in half a year, and Hummer EV delivered 90 vehicles. At present, all major electric pickup truck models have received huge orders, and the main reason that restricts their sales is that the delivery is delayed due to insufficient production capacity.

Looking at vaccines from a professional point of view, the national immunization experts answered six questions about vaccines.

Xinhua News Agency, Beijing, March 23rd (Reporter Hu Hao)The case of illegal operation of vaccines in Shandong has recently aroused public concern about vaccines: what will happen if vaccines are not transported through the cold chain? Worried that the vaccinated vaccine is invalid, do you want to replant it? What’s the difference between the first-class vaccine and the second-class vaccine in transportation and use? At the media forum organized by the National Health and Family Planning Commission on the 23rd, experts from China’s immunization program answered questions of general concern.

Why should vaccines be refrigerated? How terrible is a vaccine that is not refrigerated?

Zhao Kai, academician of China Academy of Engineering and chairman of the National Committee of Experts on Immunization Planning: Vaccines are biological products made by various pathogenic microorganisms. Some vaccines are attenuated viruses, for example, the main component of measles vaccine is attenuated measles virus, which is alive; Have a plenty of inactivated vaccine, after the bacteria are inactivated, it is an active protein, which plays an immune function.

Therefore, vaccines are delicate. For example, vaccines are afraid of heat and light, and sometimes some vaccines are afraid of freezing. In order to keep the vaccine active, cold chain should be used in transportation.

Generally speaking, if there is no cold chain during the storage and transportation of the vaccine, the activity of the vaccine will be affected more or less, but it is also related to the length of time and temperature outside the cold chain.

As for whether vaccines that have not been transported by cold chain will have adverse vaccination reactions, two factors need to be integrated. One is to investigate the cold chain situation of illegal vaccine transportation, and the other is to investigate the monitoring situation of the information management system for suspected adverse vaccination reactions.

Wang Huaqing, MD, Chief Physician of China Center for Disease Control and Prevention: Theoretically, the vaccine involved is a vaccine produced by a regular manufacturer, not a fake vaccine or a fake vaccine. It has quality control in the early stage, and the safety risk will be less. The impact of not having cold chain transportation in the later period needs to be evaluated.

What is the relationship between class I vaccine and class II vaccine? What’s the difference between management?

Wang Huaqing: A class of vaccines includes three situations. First, 14 vaccines designated by the state prevent 15 diseases. Second, the increase of the provincial health administrative department is included in the national immunization plan. The third is the emergency immunization organized by the government. For example, if there is an epidemic, emergency immunization is needed, or it is possible to predict that the disease will become popular and organize group vaccination, which all belong to the first type of vaccine.

The first type of vaccine is vaccinated free of charge; The second kind of vaccine is self-funded and voluntary.

The management of the second type of vaccine is technically the same as that of the first type of vaccine. The technical requirements are the same whether in circulation or use. However, its procurement methods are different and its supply channels are different. The procurement of the first type of vaccine is carried out by the government, and then distributed step by step through the disease control system, and finally to the inoculation unit. The second type of vaccine is based on the regulations on the management of vaccine circulation and vaccination. Production enterprises can supply it directly to business enterprises, or to disease control departments and vaccination units. Business enterprises can supply disease control institutions, vaccination units or other business enterprises. So the channels are different.

Is there any difference in quality between domestic vaccines and imported vaccines?

Zhao Kai: The technological level of domestic vaccines is completely similar to that of foreign countries. In particular, the quality of vaccines, China’s 2010 edition pharmacopoeia and the European Union’s pharmacopoeia standards are the same. Some domestic vaccines and imported vaccines have been compared or observed, and they are all the same.

Every batch of vaccines produced in China must undergo compulsory inspection and audit before they are put on the market, which is called "batch inspection". Those that fail are not allowed to go on the market. I think this quality is guaranteed.

Wang Huaqing: Actually, domestic vaccines and imported vaccines require the same standards, and they will not enter the market until they reach the standard. Most of our country uses domestic vaccines, and the control of infectious diseases in China is the contribution of domestic vaccines. If there is no domestic vaccine, the control of polio, hepatitis B and measles in China will not be so good. These are all the effects obtained by inoculating children with our own vaccines. Therefore, the final evaluation depends on whether the disease has been controlled after the application of the vaccine and whether its suspected abnormal reactions have increased. In fact, from our monitoring, there is no big difference between domestic and imported vaccines.

How to deal with vaccines near the shelf life? Is it possible to vaccinate the public with expired vaccines?

Han Cheng, director of Desheng Community Health Service Center in Xicheng District, Beijing: As a primary health service center, our vaccine procurement path is very strict, and there are also strict regulations on the validity period. Drugs that have expired in the past six months cannot enter the procurement and distribution system, and the system will automatically block them. It is impossible to enter the organization. In addition, the purchase of vaccines is on a monthly basis, and one batch is used up before entering the second batch, and it is cleaned once a month, and it is uniformly distributed and purchased by the Beijing Center for Disease Control and Prevention.

How do I know if my vaccine is a problem vaccine? Can it be traced back?

Han Chengcheng: The batch number of the vaccine can be traced back. Each child has a batch number corresponding to each medicine, which can be checked. Therefore, it can be traced back to which child a batch number was hit. The validity period of the vaccine, the time of vaccination, etc. are also completely traceable.

Wang Huaqing: When the vaccine enters the disease control system, there will be a receipt form, when it was delivered, the process of delivery, its temperature, the varieties delivered and the quantity, all of which have a complete receiving record. In the process of use, there are two records, including the parents’ signature, when and what vaccine the children took, which company and the batch number. One is the vaccination certificate in the hands of the parents, and the other is the record or vaccination card of the electronic information system.

Is it necessary to confirm whether the vaccine is effectively vaccinated by antibody testing? Is it necessary to replant the vaccine?

Wang Huaqing: If you were not vaccinated in childhood, when should you replant? Different vaccines are different, which needs to be judged again.

We are all very concerned. Did I succeed after the vaccination? The international general principle is that there is no need for testing, because if the vaccine reaches a high vaccination rate, the whole population will have a barrier.

Vaccination, under normal circumstances, does not mean that everyone produces protection, because the main function of vaccine is a group. For example, if 80% to 85% of polio is successful after taking sugar pills, polio will be blocked and eliminated.

If everyone is vaccinated, we will build this crowd barrier. If some people are vaccinated and some people are not vaccinated, the disease may become popular in the future. Therefore, to control an infectious disease, we must maintain a very high vaccination rate in vaccination, especially in the use of vaccines in the national immunization program. If the vaccination rate is not high, then the disease will become popular.