The government work report proposes to expand high-level opening to the outside world and promote mutual benefit and win-win results. Actively connect with high-standard international economic and trade rules, steadily expand institutional opening, enhance the linkage effect of two resources in the domestic and international markets, consolidate the basic disk of foreign trade and foreign investment, and cultivate new advantages in international economic cooperation and competition.

In the past year, the CPC Central Committee with the Supreme Leader as the core unswervingly promoted high-level opening up, persisted in promoting reform, development and innovation through opening up, promoted the construction of an open world economy, and opened up a broad space for development. China’s export share in the international market has remained stable, the actual use of foreign capital has been optimized, and the international influence and appeal of building the "Belt and Road" have become more prominent.

The deputies said that in the new era and new journey, we must unswervingly expand high-level opening up, continuously optimize the business environment, consolidate the basic disk of foreign trade and foreign investment, cultivate new advantages in international economic cooperation and competition, and constantly bring new impetus and opportunities to the world with our new development.

Promote a steady increase in the quality and quantity of foreign trade and accelerate the construction of a trade power.

The government work report proposes to promote a steady increase in the quality of foreign trade. The deputies said that at present, the momentum of world economic growth is insufficient and the demand is weak, but the industrial base, factor endowment and innovation ability on which China’s foreign trade development depends are constantly enhanced. We should continue to play the supporting role of exports in the economy, strengthen our confidence, go all out to stabilize foreign trade and accelerate the cultivation of new kinetic energy of foreign trade.

Expand new growth points such as intermediate trade and green trade. Representative Du Weidong, Chairman of Chongqing Xiyong Microelectronics Industrial Park Development Co., Ltd. believes that it is necessary to base on the local industrial base, cultivate new quality productivity, promote the upgrading of processing trade, increase the added value of products, and enhance the international competitiveness of Chinese enterprises and products. At present, Xiyong Microelectronics Industrial Park mainly exports smart terminals such as notebook computers, and is deeply empowered by new technologies such as naked-eye 3D and artificial intelligence (AI), which promotes the processing trade to extend to the high end of the industrial chain value chain.

Promote the healthy development of new formats such as cross-border e-commerce. "Cross-border e-commerce, as a new foreign trade format with fast development speed, great potential and strong driving effect, is becoming the development trend of international trade." Deputy Li Kuiwen, member of the Party Committee of the General Administration of Customs and director of Guangdong Branch, said. In recent years, China has continuously improved policies on customs clearance, taxation and foreign exchange, supported the reform and innovation of cross-border e-commerce comprehensive test area, cultivated and expanded cross-border e-commerce entities, optimized the layout of infrastructure such as overseas warehouses, and promoted the healthy and vigorous development of cross-border e-commerce.

Optimize the trade environment. Deputy Li Kuiwen said that as a major foreign trade province, Guangdong is actively building a high-level gateway hub for opening to the outside world, solidly promoting the construction of smart customs, implementing the action of "strengthening the country through smart customs", continuously improving the port business environment, optimizing the customs clearance operation process, and creating a market-oriented, rule-of-law and international first-class port business environment.

Increase investment and steadily expand institutional opening up.

The government work report puts forward that "more efforts should be made to attract foreign investment" and "restrictions on foreign investment access in the manufacturing sector should be completely abolished, and market access for services such as telecommunications and medical care should be relaxed".

The deputies said that to accelerate the construction of a new development pattern, it is necessary to promote the efficient connection between the domestic and international markets and resources, steadily expand the institutional opening of rules, regulations, management and standards, and build a new open economic system at a higher level.

Actively attract and utilize foreign investment. "Last year, the State Council issued opinions and put forward 24 policies and measures to stabilize foreign investment, which released China’s firm determination to promote opening up and greatly encouraged the confidence of foreign investment in China." Member Jiang Ying, the relevant person in charge of Deloitte Limited, said that China’s pragmatic measures of continuous opening-up are of great benefit to foreign investors, and Deloitte will continue to give full play to its professional advantages to help foreign-funded enterprises deepen their cultivation in China.

In-depth implementation of the promotion strategy of the Pilot Free Trade Zone to create a new highland for opening up. "Implement investment facilitation measures focusing on process supervision; The implementation of the’ non-stop flight permit’ in the transportation field has shortened the processing time by an average of 70% … Since its establishment, the Lingang New Area of Shanghai Pilot Free Trade Zone has maintained its openness, reform intensity and development momentum, and gradually formed a’ five freedoms and one convenience’ system. " Deputy Gu Jun, deputy secretary-general of Shanghai Municipal Government and director of the Municipal Development and Reform Commission, said that Shanghai will continue to benchmark the highest standards and the best level, focus on cross-border service trade and the development of leading industries, and explore the construction of an institutional system and supervision model that is linked to high-standard economic and trade rules, so as to explore new paths and accumulate new experiences for comprehensively deepening reform and opening up.

On March 1st, Hengqin Guangdong-Macao Deep Cooperation Zone officially implemented the branch line management and customs clearance operation. "Zhuhai actively meets high-standard international economic and trade rules, relies on the policy advantages of Hengqin Guangdong-Macao Deep Cooperation Zone, and allows more innovative elements to converge and overlap in Hengqin through infrastructure’ hard connectivity’ and institutional rules’ soft connectivity’ to promote the optimal combination of global industrial chain supply chains." Deputy Huang Zhihao, Deputy Secretary of Zhuhai Municipal Committee and Mayor of Guangdong Province, introduced that in the next step, Zhuhai will accelerate the construction of a new economic and trade channel for the Hong Kong-Zhuhai-Macao Bridge, expand the platform function of global cooperation for the China Air Show, and promote high-quality development through high-level opening.

Deeply participate in global industrial division of labor and cooperation, and promote the construction of an open world economy.

The deputies said that efforts should be made to promote the high-quality development of foreign trade, deeply participate in the global industrial division of labor and cooperation, maintain a pluralistic and stable international economic structure and economic and trade relations, and let more win-win results of cooperation benefit people of all countries.

Promote high-quality joint construction of the "Belt and Road" and go deep and practical. "For more than 10 years, the joint construction of the Belt and Road has achieved fruitful results and has become the most popular international public product and the largest international cooperation platform in the world today." Member Gong Fuwen, vice president of the Higher People’s Court of Shaanxi Province, said that it is necessary to do a good job in the implementation of the eight actions of building the "Belt and Road" with high quality, steadily promote cooperation in major projects, implement a number of "small but beautiful" livelihood projects, and actively promote cooperation in the fields of digital, green, innovation, health, cultural tourism and poverty alleviation.

Deepen bilateral and regional economic cooperation. Negotiate and sign high-standard free trade agreements and investment agreements with more countries and regions, promote the negotiation of the China-ASEAN Free Trade Area version 3.0, and fully and deeply participate in the WTO reform … China’s efforts to build an open world economy are progressing steadily.

"ASEAN has been China’s largest trading partner for four consecutive years, and bilateral trade and investment have continued to grow. With the in-depth implementation of the Regional Comprehensive Economic Partnership Agreement (RCEP) and the negotiation of the China-ASEAN Free Trade Area version 3.0, the potential of economic and trade cooperation is expected to be further explored. " Wei Zhaohui, Party Secretary and Director of International Expo Bureau of Guangxi Zhuang Autonomous Region, said that Guangxi will continue to hold China-ASEAN Expo with high quality, deepen and expand cooperation with ASEAN countries in the fields of commerce, trade, industry, labor, science and technology, education, etc., and show new achievements in China-ASEAN destiny community with closer service construction. (Reporter Luo Shanshan Tian Wei Huang Ford Wang Liang; Reporters Chang Qin, Li Gang, Jiang Xiaodan, Yuan Taoxiong, Zhu Jiaqi and Xie Weiqun participated in the writing)

　　Yangcheng Evening News reporter Ma Can correspondent Dai Yijun Mao Simin

　　2019 is coming to an end, and the annual Spring Festival travel rush is about to open. The reporter learned from Guangzhou Railway Group that the ticketing plan for Spring Festival travel rush in 2020 was announced a few days ago. The pre-sale period for booking tickets on the 12306 website (mobile phone client) is 30 days (including the same day), and the booking period for booking tickets by telephone is 4-30 days (including the same day), that is, tickets for the first day of January 10, 2020 will be sold on December 12, 2019.

　　According to the holiday arrangement, the holiday time for the Spring Festival in 2020 is from January 24th to January 30th. Railway Spring Festival travel rush lasts for 40 days, including 15 days before the festival and 25 days after the festival.

　　January 10th, 2020 is the first day of Spring Festival travel rush. According to the regulations that the Internet and telephone booking of railway Spring Festival travel rush train tickets are sold 30 days in advance, and the ticket window and sales outlets of stations are sold 28 days in advance, on December 12, 2019, passengers can purchase the first day train tickets of Spring Festival travel rush through the Internet and telephone.

　　January 22, 2020 (the 28th day of the twelfth lunar month) and January 23 (the 29th day of the twelfth lunar month) are the peak travel times, and the train tickets will be sold on December 24 and 25, 2019, respectively.

　　On January 29th, 2020 (the fifth day of the first month) and January 30th (the sixth day of the first month), the first wave of post-holiday return peak will be ushered in, and the return ticketing dates are December 31st, 2019 and January 1st, 2020, respectively.

　　According to the relevant person in charge of Guangzhou Railway Group, in recent years, the railway ticket sales channels have been broadened day by day, and the 12306 website (mobile phone client) has become the first choice for passengers. During the peak holiday passenger flow, the 12306 website (mobile phone client) currently accounts for more than 80% of the total ticket sales in Guangzhou Railway. At the same time, during the period of Spring Festival travel rush in 2020, Guangzhou Railway will set up 2,617 agency sales windows in Guangdong, Hunan and Qiong provinces, covering major towns and villages, and the majority of passengers can choose the nearest sales outlets to buy tickets.

　　It is worth mentioning that in the Year of the Rat, Spring Festival travel rush will continue to optimize the page experience to reduce the inconvenience that passengers may encounter in the ticket purchase process, such as the difficulty in identifying the verification code.

　　New changes in travel in Spring Festival travel rush

　　A

　　Many new lines welcome the first show.

　　A number of new high-speed rail lines have been put into operation, serving Spring Festival travel rush for the first time. Passengers should pay attention to relevant changes when traveling. For example, Beijing-Zhangjiakou high-speed railway, Chengdu-Guiyang high-speed railway, Zhangda high-speed railway and Zhanghu high-speed railway are expected to open in December. In addition, from 0: 00 on December 30, the national railways will implement the year-end major map. This also means that with the optimization and adjustment of some routes, passengers will have new choices.

　　Full coverage of electronic payment

　　With the development of science and technology, the ways and means of ticket payment in Spring Festival travel rush are more diverse and convenient than in previous years, and the station window and ticket vending machine will realize full coverage of electronic payment.

　　Guangzhou railway high-speed rail fully implements e-ticket

　　One of the major changes in Spring Festival travel rush in 2020 is that train tickets will enter the paperless era, and the use of e-tickets will become a new experience for many passengers.

　　As of December 10th, 2019, nine railways under the management of Guangzhou Railway Group, including Hainan Island High-speed Railway, Guangzhou-Zhuhai Intercity Railway, Jiangzhan Railway, Meishan Railway, nanning-guangzhou railway, Guiguang Railway, Guangzhou-Shenzhen-Hong Kong High-speed Railway, Shanghai-Kunming High-speed Railway and xiamen-shenzhen railway, have implemented e-tickets. It is estimated that on the eve of Spring Festival travel rush in 2020, all high-speed rail and intercity lines under the management of Guangzhou Railway Group will implement e-tickets.

　　After purchasing tickets through the 12306 website or mobile APP, passengers no longer need to exchange paper tickets, and they can enter and leave the station directly by swiping their ID cards or mobile phone dynamic QR codes.

　　Zhiduo d

　　● How to return and change the visa?

　　If you need to change your ticket or refund your ticket, passengers who purchase tickets by electronic payment can go through the procedures of changing your ticket or refund your ticket through the 12306 website or the designated window of the station. Passengers who have paid in cash or printed reimbursement vouchers must go to the designated window of the station.　　

　　● How to reimburse?

　　Passengers who need reimbursement can, within 30 days from the date of driving or riding, print the reimbursement voucher of e-ticket at the ticket window of the station (including the automatic ticket vending machine) with the original valid identity documents used when purchasing tickets. For the convenience of passengers, most stations have set up automatic ticket collection machines at the exit, which are used for passengers to conveniently collect reimbursement vouchers when leaving the station.

　　E-ticket reimbursement voucher, as a valuable bill certified by the national tax department, can only be processed once. Passengers are advised to print the reimbursement voucher according to the required documents and keep it properly to prevent it from being lost.

　　● What should I do if I lose my documents?

　　Passengers who lose their documents before boarding the bus, passengers with second-generation ID cards can apply for temporary identification at the railway police card-making window of the station; Passengers holding other identity documents should go to the issuing agency of the valid identity documents to apply for identity certificates, and get in and out of the station by the identity certificates. Passengers who lose their certificates on the train or before leaving the station must first go through the formalities of ticket replacement. If the seats are used normally after verification by the station, a passenger record will be issued and handed over to the passengers.　　

　　● What if I can’t buy tickets on the Internet?

　　Please rest assured! After the implementation of e-ticket, the railway department will continue to retain the traditional ticketing channels to meet the needs of elderly passengers to purchase tickets.

　　How do students use e-tickets?

　　Go to the designated ticket window or duty window of the station with your ID card and student ID card before boarding the bus, and go through the verification procedures of my resident ID card and student discount card once a year.

　　After the verification procedures are completed, you can directly check in at the station where the e-ticket has been implemented with your resident ID card and student ID card. Pay attention to cooperate with the staff to check the discount voucher after getting on the bus.

　　Other passengers who buy discount tickets also need to carry relevant preferential certificates (such as disabled soldiers Pass) with them for inspection.　　

　　● How to see the train seats when the mobile phone is out of power?

　　You can print the "ticket information sheet" in the ticket window or automatic ticket vending machine of the station, or you can scroll the big screen through the train information in the station to view the information such as the train number.

　　remind

　　E-tickets are temporarily not supported on ordinary speed lines.

　　The railway department reminded that at present, e-tickets are only implemented at the announced line stations. If passengers get on and off the stations, they can purchase e-tickets; If passengers get on the station and get off at any station that is not within the scope of implementation, and the tickets purchased are ordinary train tickets, and they buy tickets at non-implementation stations, they will still buy paper tickets according to the original ticket purchase method. For detailed information about the implementation of e-tickets, the vast number of tourists and friends can inquire through the 12306 website.

　　Take a look at the ticket raiders.

　　B

　　Pay attention to the time of ticket release

　　The opening hours of the 12306 website and telephone ticket purchase are from 6 am to 11 pm, so passengers need to pay attention to the ticket sales time and grab the ticket at the first time, which will make it more likely to buy it.

　　It should be reminded that since the pre-sale period of ticket purchase at the ticket window and sales point of the railway station is 28 days, the time for ticket purchase at the window needs to be postponed for 2 days in turn.

　　Make good use of "alternate ticket purchase"

　　Don’t worry if you don’t get the ticket the first time. The "standby ticket purchase" function has been launched on the 12306 website and APP. Each passenger can reserve four tickets for two periods for standby ticket purchase, without staring at the mobile phone. As long as someone returns a ticket or has more tickets, the system will automatically purchase them in the queue order.

　　Seize the "missing" time point

　　According to previous years’ experience, the peak of refund is 15 days before driving, followed by 1-2 days before driving. At this time, some passengers will refund their tickets because of the change of itinerary. Especially from 10: 00 pm to 11: 00 pm, it is the peak time for passengers to refund their tickets.

　　48 hours and 24 hours before driving are also good opportunities to "catch up", and the ticketing system often releases some remaining tickets.

　　Do not purchase tickets through third-party websites.

　　Don’t buy tickets through third-party purchasing websites and mobile phone clients, so as to avoid the inability to refund or change tickets online because the purchasing party fraudulently uses other people’s information, which will affect travel. Don’t provide personal information to third-party websites and mobile phone clients, so as to avoid the risk caused by personal information disclosure.

　　Did you find out?

　　You can take 13 days off in January 2020.

　　Whether the friends like it or not, the year beginning with 201× will be over. The good news is — — I don’t know if you have found out: you can rest for 13 days in January 2020!

　　New Year’s Day: January 1st holiday, a total of 1 day.

　　Spring Festival: From January 24th to 30th, there will be a holiday for 7 days. Go to work on January 19th (Sunday) and February 1st (Saturday).

　　Weekend: closed on January 4th, 5th, 11th, 12th and 18th, with a total of 5 days.

　　This edition of Cartography/Li Jinbao

Special feature of 1905 film network The appearance with a sense of high quality is one of her most eye-catching labels.Walking pictorial, the darling of fashion, became the cover queen of fashion magazines at home and abroad that year.But she is an actress, with a variety of customs and styles.She is.

Red lips with printed brocade cheongsam are graceful and pretty, without losing the charm of Qinhuai River women.

stage photo

Smoke waves flow, gestures are amorous feelings. From the eyes to the manners, it is full of flavor.He once said: "To let her play Yumo is to take a fancy to her unique temperament."

After three years of secret training, she portrayed Yumo’s mature and charming, intellectual atmosphere, meticulous, dusty and unconventional, beautiful and forbearing image, which made the original author Yan Geling full of praise.

"flowers of war" stills

In 2011, flowers of war, which won 600 million box office and became the annual Chinese box office champion, made NiNi, a 23-year-old fledgling, debut at the peak.

She has a variety of amorous feelings, and she will never be able to avoid beauty again.Her beauty is ever-changing, which can be pure and vivid.In school, NiNi, wearing a white sports school uniform, is so pure and lovely, gentle and clever, and the anise played by NiNi bears the imprint of youth, which reminds us of the youth that was shining and full of regret.

Stills of "In a hurry that year"

Long hair fluttering, beautiful in the park, she has also become a beautiful Zi Xia, smiling is full of aura.

Stills of Wukong Biography

Wearing a red dress and red lips, in the TV series "last romance", Ni Nihua is an intellectual and capable, confident and generous workplace elite Zhu Suosuo, which perfectly interprets the sentence adapted from Yi Shu’s original work: "A woman among women is dazzling."

Tv series "precious times of the past"stills

In the suspense movie, Nini is transformed into a three-faced Jiang Yuee, whose beautiful and devoted eyes are pure girls, and her cold and sharp temperament is a young woman in Leng Yan, and she is also a caring and loving mother full of tears.

Stills of "Kill"

In the TV series "Chen Xi Yuan" starring NiNi, Ni Ni performed the life of the heroine "Sansheng Sanshi" in three different states:

The spirit of the first life is lively and outgoing; Lin Mo, the second Sargam, was warm as the wind, and Ling Xi, the third, vividly interpreted the pull of humanity and divinity after returning from robbery.

Stills of TV series "Chenxiyuan"

But Ni Ni is far more than beautiful, and she can be soft and rigid.Dressed in a national costume, with a short ear-length hair, it is a combination of skill, intelligence and courage.

In the movie, NiNi lost her long hair, concealed her proud figure, and hid all kinds of amorous feelings, playing Wang Huiwu, a revolutionary figure who ran for women’s liberation, and gained an independent female force.

"1921" stills

Chivalrous women are classic and important roles in all the films, including feminine and beautiful women, heroic and rigid men, and the iron dragonfly in the movies is no exception.

"daoist magic" stills

NiNi’s heroic iron dragonfly is not only domineering, but also introverted.

In "daoist magic", she was not trapped by the face value and was not afraid of the ugliness in the play. She appeared as an ugly girl with buckteeth, and showed the rude and free-spirited side of the iron dragonfly just right. When she took off the human skin mask, the ugliness and beauty were extremely full, which was even more amazing.

Zhang Yimou once commented on NiNi: "I think she is a new type of a new era, and her future is limitless."Behind the halo, it is more of her own efforts.

NiNi and three powerful actors, Zhang zhen, and Wang, compete on the same stage, which not only has not been overshadowed, but also adds a purer stroke to the film 2.

Stills of Snow Storm

In Snowstorm, the role of doctor Sun Yan is to illuminate all crazy people. In the play, her dedication also made the crew members who performed together admire her.NiNi tried many times to go to the operating room, learn professional skills from doctors, and integrate himself into the role of forest doctors.

"Desperate Saburo" Zhang zhen said that NiNi worked harder than him, practicing more than 20 times for the lines of one word.The suffocating cold under the snowstorm can show the ultimate human nature.　

Stills of Snow Storm

When NiNi was filming a night scene where the car was trapped in a snowy mountain, the trunk of the car was open at MINUS 30 degrees, and the blower kept blowing at her for the manufacturing effect, but she still insisted on shooting it again and again.

Pang Ling, played by NiNi, is indispensable in the film. Even if sandwiched between two film emperors, NiNi’s performance is impressive.

Shock Wave 2 stills

After receiving the task from the boss, quickly seize the opportunity to make an action plan and lend a helping hand to the old love caught in the mud; At the scene of the action, we decided to suppress the pain in our hearts and issued orders in an orderly manner.

Shock Wave 2 stills

When you are sharp, you don’t want a man, and your tenderness is touching.

Shock Wave 2 stills

For more than ten years, the constantly polished acting skills are gradually pushing her forward, and the female role she plays is far more than just beauty.However, in this decade, there has never been a masterpiece in NiNi that can overshadow the light of flowers of war. For actresses, this is cruel.

Ni Ni once said: "I want to be an acting school, like an actor, and be remembered by the audience through superb acting, because beauty can’t last long."More and more excellent works make NiNi not only recognized for its beauty, but also for its advanced beauty.

Today, she loves the stage and fears the performance, and she is still quietly accumulating strength and waiting for opportunities.On the afternoon of December 11th, Movie Channel Shadow Man 1+1 will broadcast Snow Storm starring NiNi and Shock Wave 2, and NiNi, who is courageous and heroic, is worth looking forward to!

introduction

Sudden cardiac death is one of the most important problems faced by cardiologists. In many cases, the success rate of rescue is not high, so the mortality rate is still high. At present, most of the solutions are passive, and ICD (Implantable Defibrillator) is installed after patients survive, but the status quo of diagnosis and treatment of sudden cardiac death (SCD) is not optimistic. In this regard, Fuwai Hospital of China Academy of Medical SciencesProfessor Hua Wei.Report on "Current situation and challenges of prevention and treatment of sudden cardiac death in China".He mentioned that early defibrillation is the key to improve the survival rate of cardiac arrest, and early preventive implantation of ICD is the most effective means to prevent sudden cardiac death.

Sudden cardiac death is the first killer of cardiovascular disease.

The leading cause of death among adults in the United States is SCA (cardiac arrest), with an annual incidence of 450,000, which exceeds the sum of all these diseases, such as stroke (167,366), lung cancer (157,400), breast cancer (40,600) and AIDS(42156).

As a populous country, how many people have sudden cardiac death every year in China? Fuwai Hospital conducted an epidemiological survey more than ten years ago, and included the population of Beijing, Guangzhou, Shanxi and Xinjiang for sampling survey. It was the first time that the incidence of SCD in China was 418.4/100,000. If calculated by the population of 1.3 billion, the total number of sudden deaths in China was about 544,000/year, ranking first in the world.

The concept of sudden cardiac death

Definition: Sudden death due to heart causes is characterized by quickness, natural and unexpected within 1 hour after symptoms occur. About the etiology of SCA, 80% are coronary heart disease, chronic myocardial scar after myocardial infarction, acute plaque instability, rupture, bleeding and thrombosis. 10-15% are cardiomyopathy, including hypertrophic cardiomyopathy and dilated cardiomyopathy. Less than 5% of uncommon causes, such as primary electrical activity and hereditary ion channel abnormality, valvular disease or congenital heart disease, and other reasons. The triggering mechanism of SCA: transient ischemia, hemodynamic fluctuation, neurocardiovascular influence and environmental factors.

Prevention and treatment of sudden cardiac death-first aid outside the hospital

First aid outside the hospital:

Timely cardiopulmonary resuscitation and electrical defibrillation;

Most patients can not get timely and effective cardiopulmonary resuscitation;

The data shows that the popularity and effect of SCD out-of-hospital first aid are not good; According to the data of the United States in 2004, there were 166,000 cases of sudden cardiac death outside the hospital. Among them, only about 60% received emergency medical services, and the average survival rate after rescue was only 6.4%.

The above data may be lower in China.

Electrical defibrillation should be performed as soon as possible for patients with sudden cardiac death. Early defibrillation is the key to improve the survival rate of cardiac arrest.

Promote the use of AED (automated external defibrillator) in public areas with relatively high probability of witness cardiac arrest. Try to shorten the interval between stopping pressing and giving electric defibrillation, and CPR must be resumed immediately after giving electric defibrillation.

In 2010, JACC magazine reported the comparison of survival rate between CPR alone and CPR+AED for SCD patients outside the hospital. 13769 cases of SCD were selected, and only CPR was given before EMS arrived, with a survival rate of 9% (382/4 403). The survival rate was 24%(69/289) after CPR+AED treatment before EMS arrived, which was more than 2 times higher. Logistic regression results show that:AED therapy was significantly related to the survival rate of SCD patients, and the OR value was 1.75(p<0.002).

Current situation of AED configuration in China

At present, the number of defibrillators installed in public places in China is very limited, and fewer people know how to use them, which makes many patients lose the opportunity of first aid. It is difficult to carry around and play a role in time. It is impossible to issue treatment before the patient has syncope, which reduces the damage of important organs.

Prevention and Treatment of Sudden Cardiac Death —— Application of Wearable Defibrillator (WCD)

WCD can monitor the heart rhythm in real time. Once a patient has ventricular fibrillation, it can identify ventricular fibrillation in the shortest time, deliver electrode defibrillation, and effectively save the patient’s life. Automatic glue spraying during defibrillation; No conductive paste, no sticky electrode sheet; Light weight (the wearing part is only 0.815 kg); Make patient’s conscious judgment before defibrillation; Bidirectional wave 150 joules; Record and save the data 30 seconds before the heart event; Store ECG data for up to 75 minutes at a time.

AHA medical advice:

WCD technology has also been preliminarily studied in China. From June 2018 to October 2019, Fuwai Hospital and several hospitals jointly led a multi-center clinical observation study on wearable defibrillators in China. 54 patients with WCD were enrolled,Baseline information is as follows:

Indications of WCD under study:

1. Early acute myocardial infarction (within 40 days) with LVEF≤35%, 19 cases (35.2%).

2. 9 cases (16.7%) were waiting for heart transplantation and had high risk of SCD.

3. ICD could not be implanted temporarily for various reasons (such as infection), 7 cases (13.0%).

4. Newly diagnosed non-ischemic cardiomyopathy with LVEF<35%, 5 cases (9.3%).

5. Five cases (9.3%) met the secondary prevention of SCD, but the estimated survival time was less than one year.

6. ICD implantation was refused for various reasons (such as economy), 5 cases (9.3%).

7. After emergency revascularization (within 3 months), LVEF≤35%, 4 cases (7.4%).

Follow-up

1. Average wearing days: 51 34 days (longest 145 days, shortest 1 day);

2. Only 18 patients (33.3%) insisted on wearing it for one month during the three-month follow-up;

3.59.3% patients feel good about wearing; 33.3% feel ordinary when wearing;

4. The two main problems of wearing are the influence, and the size does not meet the requirements of its own body shape;

5. Only one patient was monitored for ventricular fibrillation (successful defibrillation);

6. Error-free discharge occurs.

The most effective means to prevent sudden cardiac death-implantable defibrillator (ICD)

In the United States, the annual incidence of sudden cardiac death is 250,000 to 350,000, and the average survival rate is only 5%. It is necessary to identify this high-risk patient to prevent cardiac arrest. Data show that ICD is as effective as 99% in the treatment of cardiac arrest. At the earliest, ICD needed open chest implantation, and now there are many jugular vein implants.

The progress of ICD treatment: the first ICD was implanted in the United States in 1980, approved by FDA in 1985, simple program control in 1987, hierarchical treatment in 1988, non-thoracotomy electrode lead system in 1989, biphasic ICD system in 1989, chest ICD system in 1993, unipolar defibrillation in 1993, miniaturization in 1993-1997, prolonged life and improved diagnostic ability. Now it has become a widely used method to prevent sudden cardiac death.

2017 ACC/AHA/HRS Guidelines for Patients with Ventricular Arrhythmia Management and SCD Prevention

Class I indications:

1. Survivors of SCD caused by ischemic heart disease, ventricular tachycardia or ventricular fibrillation, or stable ventricular tachycardia caused by hemodynamic instability or irreversible factors, with an estimated survival time of > 1 year, ICD implantation is recommended.

2. In patients with ischemic heart disease and syncope, if electrophysiological examination induces monomorphic sustained ventricular tachycardia and the expected survival time is more than 1 year, ICD implantation is recommended.

3. If the LVEF of ischemic heart disease is less than 35%, at least 40 days after myocardial infarction, or 90 days after revascularization, if the cardiac function is still Grade II or III on the basis of drug treatment guided by the guidelines, ICD is recommended for primary prevention.

Although ICD is a type I indication, it also has defects. After ICD is implanted in human body, its utilization rate is not very high. A prospective, non-randomized international multi-center clinical study of so-called level 1.5 prevention enrolled 3889 patients in 17 countries.

Level 1.5 prevention = level 1 prevention plus one or more items:

Non-persistent ventricular tachycardia; Frequent ventricular premature beats (> 10 beats/hour); LVEF<25%； History of syncope.

The results showed that the average follow-up was 21 10 months. Compared with the patients who did not receive ICD implantation, the all-cause mortality of the patients who received ICD implantation decreased by 49%.

The application of ICD in China, the first epicardial ICD system was implanted in 1992, and the first intravenous ICD system was implanted in China in 1996. With the formulation of ICD implantation indication guidelines and publicity and education, the number of implants has increased greatly every year since 2002. At present, about 5000-6000 patients are implanted with ICD every year in China. The proportion of primary prevention and secondary prevention in patients with ICD implantation in China is equal.

Difficulties that traditional intravenous ICD system may encounter;

Subclavian vein occlusion;

Vascular malformation;

Wear of venous lead (broken lead/broken insulation);

Difficult to pull out the lead (infection and other reasons);

The whole system needs to be removed due to infection.

In order to reduce and avoid complications caused by defibrillation leads via intravenous ICD electrodes, a brand-new technology "total subcutaneous ICD" has been developed. Vein-free lead defibrillation system, subcutaneous implantable ICD system, total subcutaneous implantation. There is no need to implant electrode leads into the heart through blood vessels to ensure the structural integrity of blood vessels. Implantation is strictly in accordance with anatomical structure, and radioscopy is not needed during implantation. The disadvantage is that pacing is not possible.

On December 23, 2014, Fuwai Hospital implanted the first SICD in China.

In 2015, ESC Guidelines recommended its Class Ⅱa:

For patients with ICD indications who do not need pacing, CRT or ATP treatment, S-ICDs should be considered as an alternative treatment for intravenous ICD.

2017 AHA/ACC/HRS VA/SCD guidelines will transfer it to Class I indications, but there are conditions: 　

"Implanting a subcutaneous cardioverter defibrillator (S-ICD) has a lower risk of infection than TV-ICD. Therefore, S-ICD is more suitable for patients with high risk of infection, such as patients with device infection, patients with end-stage renal disease, or patients with long-term immunosuppression. "

Multi-center SICD research in China and follow-up analysis of clinical application in multi-centers in implantable cardioverter defibrillator under the skin included 111 patients who successfully implanted S-ICD in 42 centers in China and had stable follow-up. The follow-up period was (272 283) d, with 39 cases of primary prevention (35.1%) and 72 cases of secondary prevention (64.9%). The results showed that 22 patients (20.8%) received 51 appropriate defibrillation treatments, and 9 patients (8.5%) had 24 inappropriate defibrillation treatments. The main cause of inappropriate defibrillation is t-wave oversensing. It is suggested that S-ICD implantation is effective and safe in China.

NEJM magazine published a prospective randomized controlled study of PRAETORIAN. This is the first prospective randomized controlled head-to-head study of S-ICD vs TV-ICD. There are 849 patients enrolled in 39 centers (Europe and the United States) in 6 countries, including 426 cases of S-ICD and 423 cases of TV-ICD. All products of TV-ICD can be enrolled (single cavity ICD), with ICD indications and meeting the requirements of S-ICD implantation.

Main end point:Compared with TV-ICD, S-ICD has non-inferiority, inappropriate electric shock, complications related to ICD system and needing intervention, and lead-related complications.

Main results:The incidence of inappropriate treatment and complications of S-ICD is similar to that of TV- ICD. The mortality of S-ICD & TV-ICD is low; The lead-related complications were significantly reduced, with 6.6% (n=24) in the control group (TV-ICD) and 6.6%(n=24) in the control group (TV-ICD).

The future and development prospect of SICD. The disadvantage of full subcutaneous ICD is that it can not effectively pace the heart. If the patient has bradycardia, he can pace bradycardia with the help of a leadless pacemaker.

Another feasible scheme, EV-ICD,Defibrillation coil is under the sternum, closer to the heart, and can conduct effective cardiac pacing. The purpose of research and development is to realize low defibrillation threshold (DFTs), small size, long service life and pacing function including ATP (anti-tachycardia pacing) through EV-ICD. This technology has been clinically studied.

EV-ICD research is a prospective, non-randomized, first long-term clinical study in human body. Patients who meet the indications of class ⅰ or ⅱ A ICD were included; Under fluoroscopy, the defibrillation lead was buried in the posterior sternum area by subcutaneous tunnel tool, and the pulse generator was placed on the left side of the chest. The defibrillation efficiency was tested by inducing fibrillation during implantation, detecting and converting ventricular fibrillation. The energy to terminate ventricular fibrillation was usually 20J once or 30J； twice in succession. Follow-up was performed at 2 weeks, 4-6 weeks and 3 months after operation. The main safety end point was no instrument or operation-related complications within 3 months after operation.

The results showed that 21 patients tried to implant, and finally 20 patients successfully implanted EV-ICD；. One patient with mediastinal fibrosis failed to be implanted successfully.

Defibrillation therapy:One patient failed to induce ventricular fibrillation/tachycardia; 89.5% patients (17/19 cases) successfully terminated ventricular fibrillation, and the defibrillation threshold was ≤30J, and the median defibrillation threshold was 15J；. The defibrillation threshold of 10.5% patients was > 30J.

Bradycardia treatment:95% patients (19/20 cases) successfully completed the pacing test, and the pacing threshold in acute phase was ≤10V, with an average of 5.1±1.9V；; R wave perception test: the average amplitude of R wave is 3.2±1.7mV；; The amplitude of R wave during ventricular fibrillation is 2.8±1.7mV, and ventricular fibrillation during operation can be correctly identified.

EV-ICD studies the clinical application experience of long-term implantation of infrasternal extravascular ICD, which proves that EV-ICD overcomes the shortcoming that SICD can’t pace, and will have a wider application prospect.

summary

Sudden cardiac death should attract our attention. The prevention and treatment of sudden cardiac death in China has a long way to go, and we need all of you to work together to reduce the occurrence of SCD in China and save more patients.

-End-　

　　The 46-episode drama "Old Tavern", starring Chen Baoguo and Amanda, tells the story of Chen Huaihai, the shopkeeper of the Shandong Old Tavern on Dalian Haoren Street, and what happened in the old Tavern he opened. Since its launch, the drama has won the love of many audiences with its rich chronological texture, solid and excellent plays, rich and full characterization and witty lines.　

　　If "Braving the Kanto" in those days was a comprehensive review of the real population migration in the history of China, today’s "Old Pub" is a multi-dimensional extension and upgrading expression of Gao Mantang’s great feelings of the "post-Braving the Kanto era" with a brand-new story context after ten years of precipitation.　　　

　　"Something nutritious for young people"

　　Today, nearly half of Dalian’s population comes from Shandong. Gao Mantang’s ancestors came to Dalian from his grandfather’s generation, and his father opened a pub on Xinglong Street in Dalian, from which the story of Old Pub originated. Gao Mantang’s deepest memory is the wonderful time after his father drank alcohol when he was a child: "My father always plays his broken erhu after drinking. Singing" Empty City Strategy "is beautiful, and singing" Xu Ce Running the City "is almost enough. If there is another Shandong Lu Opera, it is almost time to sleep." Gao Mantang’s creative desire was inspired by the legendary life stories and chivalrous feelings of his father’s wandering drinkers: "Write the stories of his father’s time with ease, and the more you write, the more energetic you are."

　　"One Lushunkou, half a modern history", with reverence for history, at the centenary of his father’s birthday, Gao Mantang finally set out to write this story that has been in his mind for thousands of times. The Old Pub was written from the national crisis in China in 1928 to 1949. Gao Mantang thought that the history of suffering in it should not be forgotten: "We should not only cherish the future, but also review the history, and remind the young people of today that when they are enjoying their lives, it is necessary for us as artists to bring them something nutritious."

　　The old pub in the play has undergone great changes for half a century, and it has been renamed several times in different years. Finally, in 2013, the name of "Shandong Old Pub" was reused. Such an old name is actually a continuation of tradition, which implies the spiritual inheritance of Do not forget your initiative mind. The Old Pub is a touching letter written by Gao Mantang to his father, a memorial to the city of Dalian, and a long and meaningful romantic poem dedicated to the audience.

　　"Everyone is in my blood."

　　In the play, Chen Huaihai is undoubtedly the most eye-catching: being a father at home and caring for his wife and children; Being a shopkeeper in a pub, caring for brothers; In Haoren Street, it is the backbone, helping the poor; He is the core of The Old Tavern and the backbone of the Chinese nation. As a descendant of the "Go to the East" people, Gao Mantang bluntly said: "I can’t educate the audience, I can only use my artistic image to infect the audience, enrich the modern people with these characteristics of Chen Huaihai, and let the traditional spirit return to our new era."

　　Chen Baoguo, who won the Flying Award for "The Old Farmer" in 2015, expressed deep gratitude to Gao Mantang at the award ceremony: "Mr. Mantang, your play is difficult to perform but long-term, and your play is an actor." For Chen Baoguo, Gao Mantang is a predecessor, a Bole, and a noble person in his artistic career; Similarly, Gao Mantang regarded him as a close friend and a soul mate in his creation. After ten years’ cooperation, they left many excellent works, and this time, The Old Tavern is a tailor-made work by Gao Mantang for Chen Baoguo. In the early stage of script creation, he had confided in Chen Baoguo many times and told him many archetypal characters and real history behind the script, which made this story take root in Chen Baoguo’s heart.

　　On the basis of Chen Huaihai as the core, The Old Tavern closely links personal destiny with feelings of home and country through group narration, and staged a legendary drama of "Every man is responsible for the rise and fall of the world". In Gao Mantang’s view, "Everyone in this room is in my blood. Chen Huaihai is equivalent to a solid main line and hub. The drinkers who come and go are branches that crisscross and merge with each other. These characters can open and close freely. "

　　"Creation should go deep into life"

　　Gao Mantang is a "rough man" born and raised in Northeast China. He has a hard-working nature in his bones. He visited six provinces and interviewed more than 200 talents to complete an old farmer. He is willing to stay in the steel plant for three years for the material of steel workers in The Age of Steel and The Great Craftsman. "Going to the East" lasted for ten years, spanning the three provinces of Heilongjiang, Kyrgyzstan and Liaoning, and reaching Jiaodong and Southwest Shandong, with a journey of tens of thousands of kilometers. In a bitter and cold place, you can only eat tofu with soy sauce to satisfy your hunger. In this regard, Gao Mantang has his own stubborn insistence: "Creation should go deep into life, take off on a solid land, and grab a handful of soil like an eagle."

　　In the pursuit of short and fast experience, creation is becoming more and more fragmented and flowing. Gao Mantang lamented this: "Such a story is too empty, not solid, and it is a suspended story. Life is the source of creation. Only by feeling, touching and experiencing can we have the impulse to create. I am willing to slow down the creative speed. With originality, China’s TV series will have long-term vitality. " (Qilu Evening News Qilu Yidian Special Reporter Tang Poetry)

　　CCTV News:Road traffic safety cannot be ignored for a moment. Recently, another scene of shock occurred in Baoding, Hebei Province.

　　A mother riding an electric bicycle, carrying her two children, ran a red light across the road and was knocked down by a car coming sideways. A boy was directly involved in the bottom of the car.

　　At about 3: 28 pm on the day of the incident, at the T-junction of the traffic lights in Chen Zhuang, Wangdu County, a woman with two children was driving an electric bicycle from north to south. At this time, the traffic lights in the north-south direction were red. The woman did not stop and wait, but did not hesitate to pass the red light; At the same time, the signal light from west to east turned green. After the signal light turned yellow and the light flashed, a white car turned left and accelerated through the intersection, just colliding with the electric bicycle, knocking it down and rolling a boy in the car under the car. After the accident, the driver of the car immediately stopped to save people and reported to the police.

　　Bai Qiumei, Hebei Baoding Traffic Police Detachment:There were three people riding the electric bicycle, mother and son, all of whom were injured to varying degrees. The boy in the back seat couldn’t afford to fall to the ground and was seriously injured. The vehicles of both sides of the accident were damaged.

　　The ambulance arrived at the scene five minutes after the accident.

　　In order to verify the situation, Wangdu traffic police retrieved the video footage of the incident. Through the video, it was found that women riding electric bicycles ran red lights, while white cars with left turns grabbed the lights and met non-motorized cyclists, which was the cause of the accident.

　　Bai Qiumei, Hebei Baoding Traffic Police Detachment:The driver of the electric (self-propelled) car, Wang Mou, and the driver of the car, Wang Moumou, should bear the same responsibility for this accident, and the passenger is not responsible.

The steady operation of the Three Gorges Project on the Yangtze River provides strong support for the implementation of the national major strategy of "transmitting electricity from the west to the east". Photo by Zheng Jiayu/Bright Picture

In the workshop of Harbin Boiler Factory Co., Ltd., workers are carrying out production operations. Xinhua news agency

Farmers in Tangshan Agricultural Park, Hebei Province drive agricultural machinery to sow peanuts in the fields. Li Xiuqing photo/bright picture

　　A few days ago, "Opinions of the Central Committee of the Communist Party of China and the State Council on Accelerating the Construction of a National Unified Market" (hereinafter referred to as "Opinions") was released. The "Opinions" clarified the overall requirements, main objectives and key tasks of accelerating the construction of a unified national market from a global and strategic perspective, which quickly attracted social attention.

　　At present, why should China speed up the construction of a unified national market? How to understand the national unified market? How to promote the "Opinions" to be implemented and see actual results?

　　Promote China’s market from big to strong.

　　Nowadays, people can buy special products from all over the country through online shopping platforms without leaving home; New formats such as 5G remote consultation allow more patients in remote areas to enjoy quality medical resources; Some auto parts manufacturers can directly transmit the technical drawings to the supplier’s production line & HELIP; &hellip;

　　"It should be noted that the rapid development and extensive penetration of next-generation information technologies such as big data and artificial intelligence are destroying all kinds of market barriers and barriers, which is of revolutionary significance for building a unified national market." Wang Yiming, vice chairman of China International Economic Exchange Center, said.

　　According to Zhong Maochu, a professor at the Institute of Economics of Nankai University, the national unified big market is a product such as land, labor, capital, technology, data, resources, and goods and services, which has formed an unmanned market among different regions, industries, groups, large and medium-sized enterprises, state-owned enterprises and private enterprises nationwide.

　　In recent years, important progress has been made in the construction of the national unified big market, but there are still some problems that hinder the construction of the national unified big market in practice.

　　Wang Yiming introduced that since the 18th National Congress of the Communist Party of China, China has adhered to the direction of socialist market economy reform, promoted market-oriented reform in breadth and depth, constantly improved systems of property rights protection, market access and fair competition, promoted price reform and market-oriented reform of important production factors such as land, capital, labor force, technology, knowledge and data, eliminated market barriers, and accelerated the formation of a modern market system.

　　"The scale of China’s domestic market ranks among the best in the world, and the scale advantage of commodity market is obvious. The scale of capital, technology, data and other factor markets is expanding rapidly, but market segmentation and local protection are more prominent, market competition is insufficient, the development of factor markets is lagging behind, and the market operation efficiency is not high. The supervision method needs to be innovated." Wang Yiming said.

　　In this regard, the "Opinions" propose to speed up the establishment of unified national market system rules, break local protection and market segmentation, open up key blocking points that restrict the economic cycle, promote the smooth flow of commodity elements and resources in a wider range, and accelerate the construction of an efficient, standardized, fair competition and fully open national unified market.

　　As the relevant person in charge of the National Development and Reform Commission said, the Opinions provide a program of action for building a unified national market in the coming period, which will certainly have an important impact on deepening reform and opening up under the new situation, making better use of the tremendous advantages of exerting, consolidating and enhancing China’s market resources, and comprehensively promoting the transformation of China’s market from large to strong.

　　Dong Yu, executive vice president of Tsinghua University China Institute of Development Planning, believes that at present, the difficulties and challenges in economic work are increasing. The central government’s layout will accelerate the construction of a unified national market, which will play a vital role in stabilizing the confidence of market players and thus stabilizing the overall development.

　　Building a high-level market circulation system

　　At present, some people have misunderstandings about the connotation, goal and realization path of the national unified market. For example, some people think that "building a unified national market means the return of the planned economy". This is a representative erroneous view.

　　"We must realize that the biggest comparative advantage of China’s economic development today is its large-scale domestic market and strong domestic demand potential." Yao Jingyuan, a special researcher in the State Council Counselor’s Office, said that building a unified national market is not a return to the planned economy, but a strong support for building a high-level socialist market economic system.

　　Chen Weiwei, an associate researcher at the Institute of Economic System and Management of the National Development and Reform Commission, said that the most striking feature of the planned economy is that enterprises produce according to the planned instructions, and their products are distributed and sold through unified channels. The purpose of building a unified national market is to get rid of market barriers and maintain fair competition. The logic behind it is to build a national big market with unified rules and regulations for all kinds of market entities and encourage diversified market entities to enter the market for fair competition; Industry authorities and local governments should not "bias", but really give "unique skills" and responsible enterprises a broader stage, and really let market price signals play a role in optimizing the allocation of resources.

　　"It can be seen that building a unified national market is not about unifying market players, distribution channels, goods and services, market prices, and nationalization." Chen Weiwei said.

　　Guo Liyan, a researcher at China Macroeconomic Research Institute, believes that a strong domestic market not only refers to a larger scale, but also refers to a modern market circulation system with more complete institutional rules, more optimized structural levels and stronger influence and attraction. This is the core energy to actively allocate domestic and foreign factor resources, a powerful engine to drive high-quality economic development, and a complete system to promote the dynamic balance between supply and demand of the national economy at a higher level and level.

　　"China has obvious advantages of super-large scale and overall market, which is an important advantage and key support for China to actively participate in reshaping the global competition pattern." Guo Liyan said that the "key measure" to comprehensively stabilize the smooth circulation of the domestic economic system is to speed up the construction of a unified national market, further cultivate and stimulate the potential of the domestic market, and resist the challenges of external uncertainty with maximum certainty.

　　Break all kinds of closed small markets

　　"The market is the bridge connecting supply and demand, the space for enterprises to compete and play games, and the realization of products and services &lsquo; The most thrilling leap &rsquo; 。” Chen Weiwei said that at present, China’s domestic market is large but not strong, and there is still great potential to be tapped. Building a unified national market can give full play to the advantages of China’s ultra-large-scale market, cultivate local world-class enterprises, attract resources with global advantages, and enhance the international discourse power of China’s market.

　　In terms of the main objectives, the Opinions clearly state that the domestic market will continue to be efficient, smooth and scale-expanding, and a stable, fair, transparent and predictable business environment will be accelerated, so as to further reduce market transaction costs, promote scientific and technological innovation and industrial upgrading, and foster new advantages in participating in international competition and cooperation.

　　It is understood that the National Development and Reform Commission and the General Administration of Market Supervision will work with relevant departments to establish and improve the departmental coordination mechanism to promote the construction of a unified national market and increase overall coordination. At the same time, clarify the phased work objectives, solve outstanding problems, and promote the reform measures to be effective as soon as possible.

　　"The key is to persist in making breakthroughs at the same time and pressing ahead. For the outstanding contradictions and problems facing the reform, we must resolutely break it and escort the overall stability with the point of reform." Dong Yu said that in order to standardize market intervention and create a stable, fair, transparent and predictable business environment, it is necessary to truly implement the concept of taking the needs of market participants as the guide and practicing the principle of simplicity, create a good ecology for all kinds of market participants to invest and start businesses, and make the process of building a unified big market become a process of constantly standardizing government behavior and reducing market intervention.

　　In Wang Yiming’s view, it is necessary to promote the construction of a unified national market through reform and innovation. To unify the rules of the market system, we should adhere to the problem-oriented principle and make innovations at the same time. We should not only deepen the reform, but also strengthen the unity of the rules of the system and the consistency of supervision and law enforcement on the basic components such as property rights system, market access, fair competition and market supervision, and also speed up the elimination of various regulations and practices that hinder the unified market and fair competition.

　　Guo Liyan said that all localities and departments should improve their positions, focus on the overall situation, obey the overall situation, give full play to the advantages of the whole country in playing a chess game and concentrating on major events, and resolutely get rid of the wrong understanding and practice of "warlord separatism" among regions and engaging in local small circulation in their own way, get rid of all kinds of closed small markets, and open up the economic cycle between different regional spaces such as "blocks", "provinces" and "cities" and "urban and rural areas".

　　On November 16th, the 6th World Sichuan Cuisine Conference officially opened in Guang ‘an, Sichuan. The conference released the Report on High-quality Development of Sichuan Cuisine Industry (2023). According to the report, by the first half of 2023, the number of stores in Sichuan cuisine had exceeded 320,000, far exceeding the number of stores in Guangdong cuisine, Jiangsu cuisine and other cuisines, and it was truly the largest cuisine in China. Spicy, spicy, green pepper and other flavors became consumers’ favorite flavors of Sichuan cuisine, which provided flavor guidance for the research and development of innovative dishes in Sichuan cuisine. It turned out that Sichuan cuisine was not just spicy. It is worth mentioning that in 2021, the Michelin list officially landed in Chengdu, becoming the fourth Michelin city after Shanghai, Beijing and Guangzhou. Do you like Sichuan food?

　　Introduction of eight Chinese cuisines;

　　The eight recognized cuisines in China are Sichuan cuisine, Guangdong cuisine, Shandong cuisine, Jiangsu cuisine, Zhejiang cuisine, Anhui cuisine, Hunan cuisine and Fujian cuisine.

　　The eight major cuisines are permeated with the Confucian spiritual pursuit of "never tire of delicacy and delicacy". After hundreds of years of inheriting ancient methods and innovation, the cooking techniques are rich and the dishes taste mellow, which has laid a good foundation for Chinese food to be fine, moderate, delicious, beautiful and healthy.

　　The characteristics of the eight major cuisines:

　　Sichuan cuisine is spicy and delicious, with heavy oil and heavy taste;

　　Cantonese cuisine is rich in color, smooth but not greasy;

　　Shandong cuisine is fresh and tender, and the soup is thick and mellow;

　　Su cuisine is fresh, crisp and rotten, with a sweet taste;

　　Zhejiang cuisine is delicious, crisp and tender, and the food is as beautiful as its scenery;

　　Anhui cuisine is simple in material selection and mellow in taste;

　　Hunan cuisine is widely used, fragrant, fresh and sour;

　　Fujian cuisine is mainly seafood, sweet, sour and salty.

one

Sichuan cuisine

Characteristics of Sichuan cuisine: spicy and delicious, famous for its rich, wide, thick and strong flavor. Enjoy the reputation of "one dish, one grid, one hundred dishes and one hundred flavors".

Representative dishes: kung pao chicken, shredded pork with fish flavor, boiled fish, pork slices for couples, etc.

　　1, kung pao chicken, with chicken as the main ingredient, supplemented by peanuts, peppers and other accessories, tastes red but not spicy, spicy but not fierce, and the meat is smooth, with crispy peanuts, which makes people drool. Legend has it that this dish was handed down from Shandong in the Qing Dynasty, and it originated from the "Fried Chicken with Sauce" in Shandong cuisine.

　　2. Fish-flavored shredded pork. This dish is made of shredded pork tenderloin fried with pickled peppers, ginger, garlic, sugar and vinegar. It is salty, fresh, sweet and sour, and the onion, ginger and garlic are rich.

　　3, boiled fish, usually made of fresh grass carp, bean sprouts, peppers and other ingredients. It is characterized by "oily but not greasy, spicy but not dry, hemp but not bitter, and tender meat".

　　4. Husband-and-wife lung slices are marinated with cow scalp, beef heart, beef tongue, tripe and beef as the main materials, then sliced, made with auxiliary materials such as Chili oil and pepper noodles, and poured with red oil. The taste is spicy and spicy.

2

Cantonese cuisine

Characteristics of Cantonese cuisine: the color is slippery but not greasy, and it pays attention to frying, frying, stewing, stewing, etc. The taste characteristics are cool, light, crisp and fresh.

Representative dishes: roast suckling pig, sweet and sour sweet and sour pork, lobster baked in soup and sweet and sour melon cups.

　　1. Roasted suckling pig: It is characterized by crispy skin, tender meat and crisp bones, and it melts in the mouth, which is one of the Guangdong roast flavors.

　　2, sweet and sour meat: golden color, crisp outside and soft inside, crispy skin and tender meat, sweet and sour taste. Enjoy a high reputation at home and abroad.

　　3. Baked lobster in soup: a seafood dish with lobster as the main ingredient and broth, especially suitable for nourishing.

　　4. Eight-treasure winter melon cup: Dice lean pork, chicken, ham, prawns, mushrooms, magnolia and scallops, add refined salt, monosodium glutamate, cooked lard and appropriate amount of water, and steam with high fire. This dish is clear and white in color, fresh and soft in wax gourd meat, and fragrant in flavor. It is a delicious seasonal delicacy.

three

Shandong cuisine

Characteristics of Shandong cuisine: strong and fresh flavor, preference for onion and garlic seasoning, especially for cooking seafood, various animal offal and soup.

Representative dishes: Jiuzhuan large intestine, stir-fried kidney flower, sweet and sour carp, fried sea cucumber with onion, fried clam with oil, stewed mullet egg soup, etc.

　　1. Jiuzhuan large intestine is a representative dish of Shandong cuisine and a traditional famous dish in Jinan City, Shandong Province. It was initiated by the owner of Jiuhualin Restaurant in Jinan in the early years of Guangxu in Qing Dynasty. It was originally called "Braised Large Intestine" and later renamed "Jiuzhuan Large Intestine". This dish is ruddy in color, soft and tender in texture, and has five flavors of sour, sweet, fragrant, spicy and salty. It was rated as "Chinese food" and one of the top ten classic dishes in Shandong.

　　2, stir-fried kidney flower, a classic dish in Shandong cuisine. The heat mastered when stir-frying kidney flowers is sweet and sour, which is the chef’s competition skill. This dish tastes particularly tender, and its lips and teeth are fragrant. It feels like slipping into the throat when eaten in the mouth, which is particularly refreshing.

　　3. Sweet and sour carp, the most representative dish of Shandong cuisine. The shape fried by carp is like carp yue longmen, which is very beautiful. After the fish body is poured with juice, it looks particularly red and bright, and its taste is crisp, sweet and sour, which has been recognized by many people.

　　4. Scallion-roasted sea cucumber is mainly made of water-soaked sea cucumber and green onion. The sea cucumber tastes soft and smooth, and the green onion is a specialty of Zhangqiu, and it tastes sweet. Sea cucumber is a kind of eight treasures, and it is also a very nutritious food, which has the functions of improving memory and preventing arteriosclerosis. So this dish is a delicious and healthy famous dish.

four

Jiangsu cuisine

Characteristics of Jiangsu cuisine: fresh, crisp and rotten, with a sweet taste. Cooking skills are famous for stewing, stewing and stewing, and attention is paid to mixing soup and keeping the original juice.

Representative dishes: Squirrel mandarin fish, duck blood vermicelli soup, Qingong meatballs, Nanjing salted duck, etc.

　　1. Squirrel mandarin fish (Sweet and Sour Mandarin Fish) is a traditional local dish in Suzhou City, Jiangsu Province. When the fried mandarin fish (or mandarin fish) is served on the table, it is immediately poured with steaming marinade, and it squeaks, hence its name because it sounds like a squirrel. Emperor Qianlong once tasted this dish. This dish is characterized by crispy outside and tender inside, orange color, sweet and sour taste and pine red fragrance.

　　2. Duck blood vermicelli soup is a traditional dish in Nanjing and an important representative dish in Jinling cuisine. Duck blood vermicelli soup is made of duck blood, duck intestines, duck liver, etc., and duck soup and vermicelli are added. It is popular all over the country because of its mild taste, fresh fragrance and smoothness, as well as the taste characteristics suitable for both north and south.

　　3. Qingong meatball is a traditional Huaiyang dish. It was once a famous tribute in the Qing Dynasty, so it is also called "Qinggong meatball". It has been made for hundreds of years and is one of the top ten famous dishes in Jiangsu Province. It is characterized by smoothness, tenderness, elasticity, white soup and delicious taste. There is a saying that "falling on the ground and jumping a few times will make your mouth tender and fragrant". Eating meatballs often also has dietotherapy effects such as fitness and beauty, tonifying the middle energizer and benefiting qi, and improving immunity.

　　4. Nanjing salted duck is a famous specialty in Nanjing and one of the important representatives of Jinling cuisine. Nanjing salted duck has a long history of making, and the salted duck skin produced is tender, fat but not greasy, delicious, fragrant, crisp and tender. In the season when osmanthus is in full bloom around Mid-Autumn Festival, the salted duck is the best in color and taste, so it is also called osmanthus duck.

five

Zhejiang cuisine

Characteristics of Zhejiang cuisine: fresh and tender, soft and smooth, mellow and glutinous, refreshing and not greasy.

Representative dishes: West Lake vinegar fish, Dongpo meat, Longjing shrimp, steamed meat with lotus leaf powder, etc.

　　1. West Lake vinegar fish, alias uncle and sister-in-law Chuanzhen, is one of the top ten classic dishes in Zhejiang and four famous dishes in Hangzhou, belonging to hangzhou dishes. The vinegar fish in the West Lake began in the Southern Song Dynasty. According to legend, Zhao Gou, Emperor Gaozong, visited the West Lake by dragon boat, tasted its fish and praised it. Later, he was regarded as the "grandmaster" of the fish. This dish is bright red in color, tender and delicious with crab flavor, sweet and sour, and unique.

　　2. Dongpo Meat, a famous dish in Hangzhou, is a return meat from Xuzhou, which is one of the "four treasures of Dongpo" in Xuzhou. According to legend, it was created by Su Dongpo. Dongpo meat is a dish with bright red color, half fat and half thin meat, fat but not greasy, and sweet and salty flavor at the entrance.

　　3. Shrimp with Longjing, a famous traditional dish in Hangzhou, Zhejiang. This dish is fresh and soft, the shrimps are white and tender, the buds and leaves are fragrant, and the color is splendid. There is tea fragrance in the shrimp, and there is shrimp fresh in the tea, which has endless aftertaste. Longjing shrimp was rated as one of the top ten classic dishes in Zhejiang Province.

　　4. Steamed pork with lotus leaf powder is a special traditional dish in Jiaxing City, Zhejiang Province, which belongs to Zhejiang cuisine. In the late Qing Dynasty, it was said that its name was related to the "Wind and Lotus in Quyuan" of the "Ten Scenes of West Lake". It is made of fresh lotus leaves from Hangzhou, fried rice flour and seasoned pork wrapped and steamed. The characteristics of steamed meat with lotus leaf powder, lotus leaf can cool blood and detoxify, the meat is crisp and rotten, the rice flour is soft and glutinous, and the meat is fragrant and fat but not greasy.

six

Hunan cuisine

Hunan cuisine is characterized by strong oil color, spicy, delicious and soft; The method of making is known as stewing, stewing, waxing, steaming and frying.

Representative famous dishes: fish head with chopped pepper, western Hunan Waipo, Jishou sour meat, Yongzhou blood duck, etc.

　　1. Chopped pepper fish head, mainly made of bighead carp fish head and chopped pepper, and steamed with soy sauce, ginger, onion, garlic and other accessories. The dishes are bright red in color, rich in flavor and tender in meat. Fat but not greasy, soft and waxy, fresh and spicy.

　　2. Pickled dried prunes (potherb mustard), dried radishes, Jiangdou Gan, shredded cabbage, etc. are used as the potherb in western Hunan, and white pepper (pepper), ginger, red dried pepper, vegetable oil, salt, garlic, chives, etc. are added and stir-fried to serve.

　　Features: spicy and delicious, bibimbap is excellent, delicious and appetizing.

　　3. Jishou sour meat is a dish made of fat pork. Materials include fat pork, refined salt, pepper powder, corn flour, dried red pepper, green garlic, peanut oil, vinegar and so on.

　　Characteristics, yellow and spicy, slightly sour, fat but not greasy, unique flavor.

　　4, Yongzhou blood duck, choose 2-3 kg of live duck, kill the duck blood for later use, and cut the duck into pieces. Add peanut oil in an iron pan. When the oil temperature is seven minutes hot, pour the chopped ginger, onion, garlic and dried red pepper into the wok and stir-fry until fragrant. Add eggplant pieces and coriander, then add duck pieces and stir-fry, and then add soup to stew. Collect juice, pour duck blood on it, stir fry, add cooking wine and pepper, pour sesame oil out of the pot.

　　Features: This dish is bright in brown and black, red in black, spicy, fresh and tender, with heavy oil, salty and palatable, and is suitable with wine and meals.

seven

Anhui cuisine

Characteristics of Anhui cuisine: simple selection of materials and mellow taste. With ham as seasoning, crystal sugar is fresh, good at stewing and paying attention to pyrotechnics.

Representative dishes: Huizhou Stinkfish, Gourd Duck, Huangshan Fang La Fish and Huizhou Yipin Pot.

　　1. Huizhou Stinkfish is a traditional dish in Huizhou. This "flavored mandarin fish" smells smelly, tastes fragrant, and the meat is tender, mellow and refreshing, keeping the original flavor of mandarin fish. Its production process is very particular, that is, fresh mandarin fish is marinated in a wooden barrel with light salt water at room temperature of about 25℃, and the fish body will give off a smelly smell. Then fry in oil pan, add pork slices and bamboo shoots, and braise in soy sauce over low heat until the soup is concentrated.

　　2, gourd duck, belonging to Huaiyang cuisine, is a traditional Suzhou dish with a long history. Its dish is shaped like a gourd, the duck meat is soft and boneless, fat but not greasy, the stuffing is loose and waxy, and the taste is fresh, salty and mellow, which is very suitable for the elderly and children.

　　3. Huangshan Fang La Fish is one of the traditional famous dishes of Anhui cuisine. Fang La, the leader of the Northern Song Rebel Army, used raw fish and shrimp to repel enemy soldiers. The locals created this dish in memory of him. This dish is mainly made of mandarin fish and shrimp, and is made by different cooking methods such as frying, sliding and steaming. It tastes salty and delicious, with sweetness in acid.

　　4. Huizhou Yipin Pot is a special hot pot food that is often eaten in Huizhou in winter. Its ingredients are very rich, including shark’s fin, abalone, hen, etc. It tastes very delicious, with good color, fragrance and taste.

eight

Fujian cuisine

Characteristics of Fujian cuisine: seafood is the main raw material, paying attention to sweet, sour, salty and fragrant, and the color is delicious and fresh.

Representative dishes: Buddha jumping wall, shredded chicken bird’s nest, emerald pearl abalone and litchi meat.

　　1. Buddha jumps over the wall, which is a famous dish among the top ten representative dishes of Fujian cuisine, so it will be served at many banquets, especially state banquets. Its ingredients are relatively expensive, such as abalone, shark’s fin and sea cucumber, but they are really delicious.

　　2, shredded chicken bird’s nest, which belongs to a relatively high-standard dish, tastes light, but it tastes particularly delicious, and it is also particularly nutritious, which is very suitable for pregnant women and the elderly.

　　3. Emerald Pearl abalone is a traditional dish in Fuzhou. With abalone and scallops as the main ingredients, it is made by seiko. Because it is shaped like jade, it is named jade pearl abalone. This dish is rich in nutrition, beautiful in shape, delicious in taste and expensive in materials, so it is naturally the top grade of the banquet.

　　4. Litchi meat is one of the traditional famous dishes in Fuzhou and one of the five representative dishes of Fujian cuisine. It has a history of more than 200 years. Litchi meat is named after its tender and smooth taste, sweet and sour taste, and its shape, color and taste are all like litchi.

On December 30, 2020, Beijing Institute of Biological Products Co., Ltd. quietly published a short announcement in official website. According to the interim analysis results of Covid-19 inactivated vaccine phase III clinical trial, the safety of Covid-19 inactivated vaccine of China Bio-Beijing Company of Sinopharm Group was good after inoculation.After two doses of immunization, the positive conversion rate of neutralizing antibody was 99.2%, and the protective power of vaccine against diseases caused by COVID-19 infection (Covid-19) was 79.34%.

Prior to this, Pfizer and Moderna from the United States also released the research results of phase III clinical trials of their own mRNA vaccines, and the protective power was over 90%. In this way, our vaccines seem to have a little poor protective effect. But be careful,This is not because our technology is not good, but more because of the congenital difference between mRNA vaccine and inactivated vaccine.

Immune protection induced by inactivated vaccine is relatively weak.

Inactivated vaccine is a vaccine made by inactivating virus by physical or chemical methods. Compared with live virus particles, the immunogenicity of inactivated virus is relatively weak, and adjuvant is often needed.

In 2013, a study entitled "Characterization of immune responses induced by activated, live attended and DNA vacuums against Japanese encephalitis virus in mice" was confirmed by Japanese encephalitis virus.Compared with artificial attenuated live vaccine and DNA vaccine, the immune response induced by inactivated vaccine is relatively weak.

Figure 1. Heading of the article

The researchers divided the mice into four groups, injected with inactivated vaccine (INV), live attenuated vaccine (LAV), DNA vaccine (pCAG-JME) and control, and then detected the antibody level in mice. At the end of the experiment, the total antibody titer induced by inactivated vaccine was significantly lower than that of attenuated live vaccine group and DNA vaccine group.

Fig. 2 Antibody level pairs induced by three vaccines

The researchers also detected the levels of different subtypes of IgG induced in the serum of mice, and found that there were differences among the three vaccines. The inactivated vaccine mainly induced IgG type 1 antibody, while the attenuated live vaccine mainly induced IgG type 2a antibody, and the antibody levels of DNA vaccine were both high.

Fig. 3 Different IgG subtypes induced by three vaccines

The researchers also compared the levels of cytokines induced by vaccine and the levels of dendritic cells and Treg in detail, and there were some differences. Anyway,There are some differences in immune response induced by inactivated vaccine, attenuated live vaccine and nucleic acid vaccine. It is not surprising that the protective effect of inactivated vaccine is not as good as that of RNA vaccine.

Inactivated vaccine has the best safety.

Because the clinical data of phase III vaccine of Beijing Institute of Biological Products have not been published in any authoritative journals,Therefore, the safety of inactivated vaccine BBIBP-CorV in China, mRNA vaccine BNT162b2 in Pfizer and mRNA vaccine mRNA-1273 in Moderna Company are examined from the published phase I/II clinical trials of vaccines.Someone has made statistics on the safety data of phase I/II clinical trials of various COVID-19 vaccines, and all the data are shown in the following figure. After the first dose of mRNA-1273 vaccine was injected, the incidence of systemic grade I adverse reactions was 53.3%, grade II adverse reactions were 13.3%, local grade I adverse reactions were 73.3%, and grade II adverse reactions were 13.3%. After injecting the second dose, the incidence of systemic first-class adverse reactions was 20%, and the incidence of second-class adverse reactions was 80%. The incidence of local first-class adverse reactions was 66.7%, and the incidence of second-class adverse reactions was 26.7%. No adverse reactions above grade 3 were found locally or systemically.

However, after injection of Pfizer’s BNT162b2, the incidence of local or systemic adverse reactions was 41.7%, and the incidence of adverse events above grade 3 was 8.3%. For people aged 65-85, the incidence of local or systemic adverse reactions is 25%, and the incidence of adverse reactions above grade 3 is 8.3%.

The results of phase I clinical trial of domestic inactivated vaccine BBIBP-CorV in China show that the incidence of first-grade local or systemic adverse reactions is 33% for people aged 18-59, and that of second-grade adverse reactions is 13%. For people over 60, the incidence of adverse reactions is 29%, and there are no adverse events above grade 3. In the results of Phase II clinical trials, the incidence of Grade I adverse events was 15%, and the incidence of Grade II adverse events was 2%.

Fig. 4 Adverse reactions of various vaccines.

Judging from these data, among the three popular vaccines at present, the safety of inactivated vaccine in China is absolutely the best, not to mention the recent allergic storm of Pfizer vaccine, which has caused rare allergic reactions in dozens of people.

Domestic vaccines with 79% protection and no serious adverse reactions are absolutely safe and effective.Because China’s epidemic prevention and control work is very well done, we have to overcome many difficulties when conducting clinical trials of vaccines. After all, the epidemic situation in COVID-19 is well controlled and there is no condition for clinical trials, which is one of the reasons why the progress of phase III clinical trials lags behind others. We should see that even if our protection efficiency does not exceed 90% in the United States, inactivated vaccine obviously has advantages, such as it is safer and easier to store and transport. Although our protective effect is not as good as the two vaccines in the United States, it has reached the standard of vaccine approval, and the protective effect far exceeds 50%, which is trustworthy.

　　Recently, the Anti-smuggling Bureau of Guangzhou Customs, with the assistance of the Anti-smuggling Bureaus of Huangpu, Jiangmen, Kunming and Nanning, launched the "Fighting 28" special campaign to crack down on the smuggling of imported fruits, successfully destroyed three smuggling criminal gangs and arrested 12 suspects, involving a case value of about 1.355 billion yuan.

　　The smuggling gang involved in the case has been purchasing mangosteen, longan, durian and other fruits of Thai origin overseas for a long time in the name of a company in Guangzhou, and after transporting them to the borders of Guangxi and Yunnan, the local smuggling gang responsible for customs clearance declared imports through border small-scale trade and general trade by falsely reporting the origin and underreporting the price, and sold them to Guangzhou and other places for profit. In addition, it was found that smuggling gangs smuggled fruits in the border market under the guise of "border residents".

　　At present, the case is under further investigation. Guangzhou Customs will resolutely implement the deployment of the special action of "National Sword 2020" of the General Administration of Customs, and resolutely crack down on smuggling crimes by relying on the working mechanism of "smuggling by all staff" to safeguard the "safety at the table" of ordinary people.